Integration of microwave tomography with magnetic resonance for improved breast imaging

Paul M. Meaney, Amir Golnabi, Neil R. Epstein, Shireen D. Geimer, Margaret W. Fanning, John B. Weaver, Keith D. Paulsen

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Purpose: Breast magnetic resonance imaging is highly sensitive but not very specific for the detection of breast cancer. Opportunities exist to supplement the image acquisition with a more specific modality provided the technical challenges of meeting space limitations inside the bore, restricted breast access, and electromagnetic compatibility requirements can be overcome. Magnetic resonance (MR) and microwave tomography (MT) are complementary and synergistic because the high resolution of MR is used to encode spatial priors on breast geometry and internal parenchymal features that have distinct electrical properties (i.e., fat vs fibroglandular tissue) for microwave tomography. Methods: The authors have overcome integration challenges associated with combining MT with MR to produce a new coregistered, multimodality breast imaging platform-magnetic resonance microwave tomography, including: substantial illumination tank size reduction specific to the confined MR bore diameter, minimization of metal content and composition, reduction of metal artifacts in the MR images, and suppression of unwanted MT multipath signals. Results: MR SNR exceeding 40 dB can be obtained. Proper filtering of MR signals reduces MT data degradation allowing MT SNR of 20 dB to be obtained, which is sufficient for image reconstruction. When MR spatial priors are incorporated into the recovery of MT property estimates, the errors between the recovered versus actual dielectric properties approach 5%. Conclusions: The phantom and human subject exams presented here are the first demonstration of combining MT with MR to improve the accuracy of the reconstructed MT images.

Original languageEnglish
Article number103101
JournalMedical Physics
Volume40
Issue number10
DOIs
StatePublished - 1 Jan 2013

Fingerprint

Microwaves
Breast
Magnetic Resonance Spectroscopy
Tomography
Metals
Magnetic Resonance Imaging
Computer-Assisted Image Processing
Electromagnetic Phenomena
Lighting
Artifacts
Fats
Breast Neoplasms

Keywords

  • Breast cancer
  • MRI
  • Microwave tomography
  • Multimodal imaging
  • Specificity enhancement

Cite this

Meaney, P. M., Golnabi, A., Epstein, N. R., Geimer, S. D., Fanning, M. W., Weaver, J. B., & Paulsen, K. D. (2013). Integration of microwave tomography with magnetic resonance for improved breast imaging. Medical Physics, 40(10), [103101]. https://doi.org/10.1118/1.4820361
Meaney, Paul M. ; Golnabi, Amir ; Epstein, Neil R. ; Geimer, Shireen D. ; Fanning, Margaret W. ; Weaver, John B. ; Paulsen, Keith D. / Integration of microwave tomography with magnetic resonance for improved breast imaging. In: Medical Physics. 2013 ; Vol. 40, No. 10.
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Meaney, PM, Golnabi, A, Epstein, NR, Geimer, SD, Fanning, MW, Weaver, JB & Paulsen, KD 2013, 'Integration of microwave tomography with magnetic resonance for improved breast imaging', Medical Physics, vol. 40, no. 10, 103101. https://doi.org/10.1118/1.4820361

Integration of microwave tomography with magnetic resonance for improved breast imaging. / Meaney, Paul M.; Golnabi, Amir; Epstein, Neil R.; Geimer, Shireen D.; Fanning, Margaret W.; Weaver, John B.; Paulsen, Keith D.

In: Medical Physics, Vol. 40, No. 10, 103101, 01.01.2013.

Research output: Contribution to journalArticle

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AU - Meaney, Paul M.

AU - Golnabi, Amir

AU - Epstein, Neil R.

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AU - Weaver, John B.

AU - Paulsen, Keith D.

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