Interaction between genetic variants and exposure to Hurricane Katrina on post-traumatic stress and post-traumatic growth

A prospective analysis of low income adults

Erin C. Dunn, Nadia Solovieff, Sarah Lowe, Patience J. Gallagher, Jonathan Chaponis, Jonathan Rosand, Karestan C. Koenen, Mary C. Waters, Jean E. Rhodes, Jordan W. Smoller

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30 Citations (Scopus)

Abstract

Background There is considerable variation in psychological reactions to natural disasters, with responses ranging from relatively mild and transitory symptoms to severe and persistent posttraumatic stress (PTS). Some survivors also report post-traumatic growth (PTG), or positive psychological changes due to the experience and processing of the disaster and its aftermath. Gene-environment interaction (GxE) studies could offer new insight into the factors underlying variability in post-disaster psychological responses. However, few studies have explored GxE in a disaster context. Methods We examined whether ten common variants in seven genes (BDNF, CACNA1C, CRHR1, FKBP5, OXTR, RGS2, SLC6A4) modified associations between Hurricane Katrina exposure and PTS and PTG. Data were from a prospective study of 205 low-income non-Hispanic Black parents residing in New Orleans prior to and following Hurricane Katrina. Results We found a significant association (after correction) between RGS2 (rs4606; p=0.0044) and PTG, which was mainly driven by a cross-over GxE (p=0.006), rather than a main genetic effect (p=0.071). The G (minor allele) was associated with lower PTG scores for low levels of Hurricane exposure and higher PTG scores for moderate and high levels of exposure. We also found a nominally significant association between variation in FKBP5 (rs1306780, p=0.0113) and PTG, though this result did not survive correction for multiple testing. Limitations Although the inclusion of low-income non-Hispanic Black parents allowed us to examine GxE among a highly vulnerable group, our findings may not generalize to other populations or groups experiencing other natural disasters. Moreover, not all participants invited to participate in the genetic study provided saliva. Conclusions To our knowledge, this is the first study to identify GxE in the context of post-traumatic growth. Future studies are needed to clarify the role of GxE in PTS and PTG and post-disaster psychological responses, especially among vulnerable populations.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalJournal of Affective Disorders
Volume152-154
Issue number1
DOIs
StatePublished - 1 Jan 2014

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Cyclonic Storms
Disasters
Growth
Psychology
Parents
Gene-Environment Interaction
Brain-Derived Neurotrophic Factor
Vulnerable Populations
Saliva
Population Groups
Survivors
Alleles
Prospective Studies

Keywords

  • Adversity
  • Genes
  • Hurricane
  • Post-traumatic growth
  • Post-traumatic stress
  • Resilience

Cite this

Dunn, Erin C. ; Solovieff, Nadia ; Lowe, Sarah ; Gallagher, Patience J. ; Chaponis, Jonathan ; Rosand, Jonathan ; Koenen, Karestan C. ; Waters, Mary C. ; Rhodes, Jean E. ; Smoller, Jordan W. / Interaction between genetic variants and exposure to Hurricane Katrina on post-traumatic stress and post-traumatic growth : A prospective analysis of low income adults. In: Journal of Affective Disorders. 2014 ; Vol. 152-154, No. 1. pp. 243-249.
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title = "Interaction between genetic variants and exposure to Hurricane Katrina on post-traumatic stress and post-traumatic growth: A prospective analysis of low income adults",
abstract = "Background There is considerable variation in psychological reactions to natural disasters, with responses ranging from relatively mild and transitory symptoms to severe and persistent posttraumatic stress (PTS). Some survivors also report post-traumatic growth (PTG), or positive psychological changes due to the experience and processing of the disaster and its aftermath. Gene-environment interaction (GxE) studies could offer new insight into the factors underlying variability in post-disaster psychological responses. However, few studies have explored GxE in a disaster context. Methods We examined whether ten common variants in seven genes (BDNF, CACNA1C, CRHR1, FKBP5, OXTR, RGS2, SLC6A4) modified associations between Hurricane Katrina exposure and PTS and PTG. Data were from a prospective study of 205 low-income non-Hispanic Black parents residing in New Orleans prior to and following Hurricane Katrina. Results We found a significant association (after correction) between RGS2 (rs4606; p=0.0044) and PTG, which was mainly driven by a cross-over GxE (p=0.006), rather than a main genetic effect (p=0.071). The G (minor allele) was associated with lower PTG scores for low levels of Hurricane exposure and higher PTG scores for moderate and high levels of exposure. We also found a nominally significant association between variation in FKBP5 (rs1306780, p=0.0113) and PTG, though this result did not survive correction for multiple testing. Limitations Although the inclusion of low-income non-Hispanic Black parents allowed us to examine GxE among a highly vulnerable group, our findings may not generalize to other populations or groups experiencing other natural disasters. Moreover, not all participants invited to participate in the genetic study provided saliva. Conclusions To our knowledge, this is the first study to identify GxE in the context of post-traumatic growth. Future studies are needed to clarify the role of GxE in PTS and PTG and post-disaster psychological responses, especially among vulnerable populations.",
keywords = "Adversity, Genes, Hurricane, Post-traumatic growth, Post-traumatic stress, Resilience",
author = "Dunn, {Erin C.} and Nadia Solovieff and Sarah Lowe and Gallagher, {Patience J.} and Jonathan Chaponis and Jonathan Rosand and Koenen, {Karestan C.} and Waters, {Mary C.} and Rhodes, {Jean E.} and Smoller, {Jordan W.}",
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Dunn, EC, Solovieff, N, Lowe, S, Gallagher, PJ, Chaponis, J, Rosand, J, Koenen, KC, Waters, MC, Rhodes, JE & Smoller, JW 2014, 'Interaction between genetic variants and exposure to Hurricane Katrina on post-traumatic stress and post-traumatic growth: A prospective analysis of low income adults', Journal of Affective Disorders, vol. 152-154, no. 1, pp. 243-249. https://doi.org/10.1016/j.jad.2013.09.018

Interaction between genetic variants and exposure to Hurricane Katrina on post-traumatic stress and post-traumatic growth : A prospective analysis of low income adults. / Dunn, Erin C.; Solovieff, Nadia; Lowe, Sarah; Gallagher, Patience J.; Chaponis, Jonathan; Rosand, Jonathan; Koenen, Karestan C.; Waters, Mary C.; Rhodes, Jean E.; Smoller, Jordan W.

In: Journal of Affective Disorders, Vol. 152-154, No. 1, 01.01.2014, p. 243-249.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Interaction between genetic variants and exposure to Hurricane Katrina on post-traumatic stress and post-traumatic growth

T2 - A prospective analysis of low income adults

AU - Dunn, Erin C.

AU - Solovieff, Nadia

AU - Lowe, Sarah

AU - Gallagher, Patience J.

AU - Chaponis, Jonathan

AU - Rosand, Jonathan

AU - Koenen, Karestan C.

AU - Waters, Mary C.

AU - Rhodes, Jean E.

AU - Smoller, Jordan W.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background There is considerable variation in psychological reactions to natural disasters, with responses ranging from relatively mild and transitory symptoms to severe and persistent posttraumatic stress (PTS). Some survivors also report post-traumatic growth (PTG), or positive psychological changes due to the experience and processing of the disaster and its aftermath. Gene-environment interaction (GxE) studies could offer new insight into the factors underlying variability in post-disaster psychological responses. However, few studies have explored GxE in a disaster context. Methods We examined whether ten common variants in seven genes (BDNF, CACNA1C, CRHR1, FKBP5, OXTR, RGS2, SLC6A4) modified associations between Hurricane Katrina exposure and PTS and PTG. Data were from a prospective study of 205 low-income non-Hispanic Black parents residing in New Orleans prior to and following Hurricane Katrina. Results We found a significant association (after correction) between RGS2 (rs4606; p=0.0044) and PTG, which was mainly driven by a cross-over GxE (p=0.006), rather than a main genetic effect (p=0.071). The G (minor allele) was associated with lower PTG scores for low levels of Hurricane exposure and higher PTG scores for moderate and high levels of exposure. We also found a nominally significant association between variation in FKBP5 (rs1306780, p=0.0113) and PTG, though this result did not survive correction for multiple testing. Limitations Although the inclusion of low-income non-Hispanic Black parents allowed us to examine GxE among a highly vulnerable group, our findings may not generalize to other populations or groups experiencing other natural disasters. Moreover, not all participants invited to participate in the genetic study provided saliva. Conclusions To our knowledge, this is the first study to identify GxE in the context of post-traumatic growth. Future studies are needed to clarify the role of GxE in PTS and PTG and post-disaster psychological responses, especially among vulnerable populations.

AB - Background There is considerable variation in psychological reactions to natural disasters, with responses ranging from relatively mild and transitory symptoms to severe and persistent posttraumatic stress (PTS). Some survivors also report post-traumatic growth (PTG), or positive psychological changes due to the experience and processing of the disaster and its aftermath. Gene-environment interaction (GxE) studies could offer new insight into the factors underlying variability in post-disaster psychological responses. However, few studies have explored GxE in a disaster context. Methods We examined whether ten common variants in seven genes (BDNF, CACNA1C, CRHR1, FKBP5, OXTR, RGS2, SLC6A4) modified associations between Hurricane Katrina exposure and PTS and PTG. Data were from a prospective study of 205 low-income non-Hispanic Black parents residing in New Orleans prior to and following Hurricane Katrina. Results We found a significant association (after correction) between RGS2 (rs4606; p=0.0044) and PTG, which was mainly driven by a cross-over GxE (p=0.006), rather than a main genetic effect (p=0.071). The G (minor allele) was associated with lower PTG scores for low levels of Hurricane exposure and higher PTG scores for moderate and high levels of exposure. We also found a nominally significant association between variation in FKBP5 (rs1306780, p=0.0113) and PTG, though this result did not survive correction for multiple testing. Limitations Although the inclusion of low-income non-Hispanic Black parents allowed us to examine GxE among a highly vulnerable group, our findings may not generalize to other populations or groups experiencing other natural disasters. Moreover, not all participants invited to participate in the genetic study provided saliva. Conclusions To our knowledge, this is the first study to identify GxE in the context of post-traumatic growth. Future studies are needed to clarify the role of GxE in PTS and PTG and post-disaster psychological responses, especially among vulnerable populations.

KW - Adversity

KW - Genes

KW - Hurricane

KW - Post-traumatic growth

KW - Post-traumatic stress

KW - Resilience

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U2 - 10.1016/j.jad.2013.09.018

DO - 10.1016/j.jad.2013.09.018

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