Interhemispheric asymmetry of motor cortical excitability in major depression as measured by transcranial magnetic stimulation

F. Maeda, Julian Keenan, A. Pascual-Leone

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Abstract

Background: Neuroimaging studies of major depressive disorder (MDD) indicate interhemispheric differences in prefrontal cortical activity (right greater than left). Aims: To investigate whether there are any interhemispheric differences of motor cortical excitability in MDD. Method: Eight patients with treatment-refractory MDD off medication were assessed for the severity of their depression, and transcranial magnetic stimulation studies (bilateral motor threshold and paired-pulse studies) were conducted. Eight normal controls were also studied. Results: MDD patients showed significant interhemispheric differences in motor threshold and paired-pulse curves, both of which showed lower excitability on the left hemisphere. Such differences were absent in controls. Conclusions: Our findings may aid the further understanding of the neurophysiology underlying MDD. Declaration of interest This study was supported in part by the Cellular Science Research Foundation, Yoshida Science Foundation, Stanley Vada Foundation, National Alliance for Research in Schizophrenia and Depression, and the National Institute of Mental Health (ROIMH57980).

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalBritish Journal of Psychiatry
Volume177
Issue numberAUG.
DOIs
StatePublished - 29 Aug 2000

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Transcranial Magnetic Stimulation
Major Depressive Disorder
Depression
National Institute of Mental Health (U.S.)
Neurophysiology
Research
Neuroimaging
Schizophrenia
Cortical Excitability

Cite this

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title = "Interhemispheric asymmetry of motor cortical excitability in major depression as measured by transcranial magnetic stimulation",
abstract = "Background: Neuroimaging studies of major depressive disorder (MDD) indicate interhemispheric differences in prefrontal cortical activity (right greater than left). Aims: To investigate whether there are any interhemispheric differences of motor cortical excitability in MDD. Method: Eight patients with treatment-refractory MDD off medication were assessed for the severity of their depression, and transcranial magnetic stimulation studies (bilateral motor threshold and paired-pulse studies) were conducted. Eight normal controls were also studied. Results: MDD patients showed significant interhemispheric differences in motor threshold and paired-pulse curves, both of which showed lower excitability on the left hemisphere. Such differences were absent in controls. Conclusions: Our findings may aid the further understanding of the neurophysiology underlying MDD. Declaration of interest This study was supported in part by the Cellular Science Research Foundation, Yoshida Science Foundation, Stanley Vada Foundation, National Alliance for Research in Schizophrenia and Depression, and the National Institute of Mental Health (ROIMH57980).",
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Interhemispheric asymmetry of motor cortical excitability in major depression as measured by transcranial magnetic stimulation. / Maeda, F.; Keenan, Julian; Pascual-Leone, A.

In: British Journal of Psychiatry, Vol. 177, No. AUG., 29.08.2000, p. 169-173.

Research output: Contribution to journalArticleResearchpeer-review

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