Interindividual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability

Fumiko Maeda, Julian Keenan, Jose M. Tormos, Helge Topka, Alvaro Pascual-Leone

Research output: Contribution to journalArticle

370 Citations (Scopus)

Abstract

Repetitive transcranial magnetic stimulation (rTMS) appears to have effects on cortical excitability that extend beyond the train of rTMS itself. These effects may be inhibitory or facilitatory and appear to depend on the frequency, intensity, duration and intertrain interval of the rTMS. Many studies assume facilitatory effects of high-frequency rTMS and inhibitory effects of low-frequency rTMS. Nevertheless, the interindividual variability of this modulation of cortical excitability by rTMS has not been systematically investigated. In this study, we applied 240 pulses of rTMS at 90% of the subjects' motor threshold to their motor cortex at different frequencies (1, 10, 15 and 20 Hz) and examined the effects on motor evoked potentials (frequency tuning curve). Although the averaged group data showed a frequency-dependent increase in cortical excitability, each subject had a different pattern of frequency tuning curve, i.e. a different modulatory effect on cortical excitability at different rTMS frequencies. The interindividual variability of these modulatory effects was still high, though less so, when the number of rTMS pulses was increased to 1600. These findings illustrate the degree of variability of the rTMS effects in the human brain.

Original languageEnglish
Pages (from-to)425-430
Number of pages6
JournalExperimental Brain Research
Volume133
Issue number4
DOIs
StatePublished - 19 Aug 2000

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Transcranial Magnetic Stimulation
Cortical Excitability
Motor Evoked Potentials
Motor Cortex

Keywords

  • (rTMS)
  • Cortical excitability
  • Frequency tuning curve
  • Neurophysiology
  • Repetitive transcranial magnetic stimulation
  • Train

Cite this

Maeda, Fumiko ; Keenan, Julian ; Tormos, Jose M. ; Topka, Helge ; Pascual-Leone, Alvaro. / Interindividual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability. In: Experimental Brain Research. 2000 ; Vol. 133, No. 4. pp. 425-430.
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Interindividual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability. / Maeda, Fumiko; Keenan, Julian; Tormos, Jose M.; Topka, Helge; Pascual-Leone, Alvaro.

In: Experimental Brain Research, Vol. 133, No. 4, 19.08.2000, p. 425-430.

Research output: Contribution to journalArticle

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