Long-term outcome of vagus nerve stimulation therapy in patients with refractory epilepsy

Abuhuziefa Abubakr, Ilse Wambacq

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

We retrospectively assessed the long-term efficacy of vagus nerve stimulation (VNS) therapy in 31 patients with refractory partial and generalized seizures who were not candidates for resective epilepsy surgery. Following implantation of VNS there was significant improvement in seizure frequency at 6 months. Sixteen patients continued to have sustained response to VNS therapy 4 years later. Adverse effects of VNS therapy were transient and tolerable. The majority of the patients did not gain body weight and some of them had significant weight loss. Therefore VNS is safe and effective therapy and has a long-term sustained effect in refractory epilepsy.

Original languageEnglish
Pages (from-to)127-129
Number of pages3
JournalJournal of Clinical Neuroscience
Volume15
Issue number2
DOIs
StatePublished - 1 Feb 2008

Fingerprint

Vagus Nerve Stimulation
Epilepsy
Seizures
Therapeutics
Weight Loss
Body Weight

Keywords

  • Refractory epilepsy
  • Responder
  • VNS
  • Weight loss

Cite this

@article{4f367b3733bb455b98b5fe288c86cf89,
title = "Long-term outcome of vagus nerve stimulation therapy in patients with refractory epilepsy",
abstract = "We retrospectively assessed the long-term efficacy of vagus nerve stimulation (VNS) therapy in 31 patients with refractory partial and generalized seizures who were not candidates for resective epilepsy surgery. Following implantation of VNS there was significant improvement in seizure frequency at 6 months. Sixteen patients continued to have sustained response to VNS therapy 4 years later. Adverse effects of VNS therapy were transient and tolerable. The majority of the patients did not gain body weight and some of them had significant weight loss. Therefore VNS is safe and effective therapy and has a long-term sustained effect in refractory epilepsy.",
keywords = "Refractory epilepsy, Responder, VNS, Weight loss",
author = "Abuhuziefa Abubakr and Ilse Wambacq",
year = "2008",
month = "2",
day = "1",
doi = "10.1016/j.jocn.2007.07.083",
language = "English",
volume = "15",
pages = "127--129",
journal = "Journal of Clinical Neuroscience",
issn = "0967-5868",
publisher = "Churchill Livingstone",
number = "2",

}

Long-term outcome of vagus nerve stimulation therapy in patients with refractory epilepsy. / Abubakr, Abuhuziefa; Wambacq, Ilse.

In: Journal of Clinical Neuroscience, Vol. 15, No. 2, 01.02.2008, p. 127-129.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Long-term outcome of vagus nerve stimulation therapy in patients with refractory epilepsy

AU - Abubakr, Abuhuziefa

AU - Wambacq, Ilse

PY - 2008/2/1

Y1 - 2008/2/1

N2 - We retrospectively assessed the long-term efficacy of vagus nerve stimulation (VNS) therapy in 31 patients with refractory partial and generalized seizures who were not candidates for resective epilepsy surgery. Following implantation of VNS there was significant improvement in seizure frequency at 6 months. Sixteen patients continued to have sustained response to VNS therapy 4 years later. Adverse effects of VNS therapy were transient and tolerable. The majority of the patients did not gain body weight and some of them had significant weight loss. Therefore VNS is safe and effective therapy and has a long-term sustained effect in refractory epilepsy.

AB - We retrospectively assessed the long-term efficacy of vagus nerve stimulation (VNS) therapy in 31 patients with refractory partial and generalized seizures who were not candidates for resective epilepsy surgery. Following implantation of VNS there was significant improvement in seizure frequency at 6 months. Sixteen patients continued to have sustained response to VNS therapy 4 years later. Adverse effects of VNS therapy were transient and tolerable. The majority of the patients did not gain body weight and some of them had significant weight loss. Therefore VNS is safe and effective therapy and has a long-term sustained effect in refractory epilepsy.

KW - Refractory epilepsy

KW - Responder

KW - VNS

KW - Weight loss

UR - http://www.scopus.com/inward/record.url?scp=37548999802&partnerID=8YFLogxK

U2 - 10.1016/j.jocn.2007.07.083

DO - 10.1016/j.jocn.2007.07.083

M3 - Article

VL - 15

SP - 127

EP - 129

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

SN - 0967-5868

IS - 2

ER -