Long-term outcome of vagus nerve stimulation therapy in patients with refractory epilepsy

Abuhuziefa Abubakr, Ilse Wambacq

Research output: Contribution to journalArticle

25 Scopus citations


We retrospectively assessed the long-term efficacy of vagus nerve stimulation (VNS) therapy in 31 patients with refractory partial and generalized seizures who were not candidates for resective epilepsy surgery. Following implantation of VNS there was significant improvement in seizure frequency at 6 months. Sixteen patients continued to have sustained response to VNS therapy 4 years later. Adverse effects of VNS therapy were transient and tolerable. The majority of the patients did not gain body weight and some of them had significant weight loss. Therefore VNS is safe and effective therapy and has a long-term sustained effect in refractory epilepsy.

Original languageEnglish
Pages (from-to)127-129
Number of pages3
JournalJournal of Clinical Neuroscience
Issue number2
Publication statusPublished - 1 Feb 2008



  • Refractory epilepsy
  • Responder
  • VNS
  • Weight loss

Cite this