Mathematically modeling the role of triglyceride production on leptin resistance

Yu Zhao, Daniel Burkow, Baojun Song

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Abstract

Diet-induced obesity is becoming more common all over the world, which is increasing the prevalence of obesity-induced chronic diseases such as diabetes, coronary heart disease, cancer, and sleep apnea. Many experimental results show that obesity is often associated with an elevated concentration of plasma leptin and triglycerides. Triglycerides inhibit the passage of leptin across the blood–brain barrier (BBB) to signal the hypothalamus to suppress appetite. However, it is still not clear how triglyceride concentration affects leptin transport across the BBB and energy balance. In this paper, we propose a novel ordinary differential equations model describing the role of leptin in the regulation of adipose tissue mass. Analytical and numerical results are analyzed using biologically relevant parameter values. Additionally, we perform sensitivity analysis of the equilibria and study the sensitivity of triglyceride production on leptin resistance. Equilibria analysis and simulation results show that triglyceride production plays an important role in determining the fat mass in an individual. As weight increases, the occurrence of leptin resistance increases. Obesity enhances the likelihood of creating a vicious circle, where more fat mass leads to greater leptin resistance. Thus, control of the triglyceride production may be effective in reducing the occurrence of leptin resistance.

Original languageEnglish
Title of host publicationRecent Developments in Intelligent Computing, Communication and Devices - Proceedings of ICCD 2017
EditorsSrikanta Patnaik, Vipul Jain
PublisherSpringer Verlag
Pages291-301
Number of pages11
ISBN (Print)9789811089435
DOIs
StatePublished - 1 Jan 2019
EventInternational Conference on Intelligent Computing, Communication and Devices, ICCD 2017 - Shenzhen, China
Duration: 9 Dec 201710 Dec 2017

Publication series

NameAdvances in Intelligent Systems and Computing
Volume752
ISSN (Print)2194-5357

Other

OtherInternational Conference on Intelligent Computing, Communication and Devices, ICCD 2017
CountryChina
CityShenzhen
Period9/12/1710/12/17

Fingerprint

Oils and fats
Nutrition
Medical problems
Energy balance
Ordinary differential equations
Sensitivity analysis
Triglycerides
Tissue
Plasmas
Sleep

Keywords

  • Bifurcation
  • Leptin resistance
  • Sensitivity
  • Triglyceride

Cite this

Zhao, Y., Burkow, D., & Song, B. (2019). Mathematically modeling the role of triglyceride production on leptin resistance. In S. Patnaik, & V. Jain (Eds.), Recent Developments in Intelligent Computing, Communication and Devices - Proceedings of ICCD 2017 (pp. 291-301). (Advances in Intelligent Systems and Computing; Vol. 752). Springer Verlag. https://doi.org/10.1007/978-981-10-8944-2_35
Zhao, Yu ; Burkow, Daniel ; Song, Baojun. / Mathematically modeling the role of triglyceride production on leptin resistance. Recent Developments in Intelligent Computing, Communication and Devices - Proceedings of ICCD 2017. editor / Srikanta Patnaik ; Vipul Jain. Springer Verlag, 2019. pp. 291-301 (Advances in Intelligent Systems and Computing).
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Zhao, Y, Burkow, D & Song, B 2019, Mathematically modeling the role of triglyceride production on leptin resistance. in S Patnaik & V Jain (eds), Recent Developments in Intelligent Computing, Communication and Devices - Proceedings of ICCD 2017. Advances in Intelligent Systems and Computing, vol. 752, Springer Verlag, pp. 291-301, International Conference on Intelligent Computing, Communication and Devices, ICCD 2017, Shenzhen, China, 9/12/17. https://doi.org/10.1007/978-981-10-8944-2_35

Mathematically modeling the role of triglyceride production on leptin resistance. / Zhao, Yu; Burkow, Daniel; Song, Baojun.

Recent Developments in Intelligent Computing, Communication and Devices - Proceedings of ICCD 2017. ed. / Srikanta Patnaik; Vipul Jain. Springer Verlag, 2019. p. 291-301 (Advances in Intelligent Systems and Computing; Vol. 752).

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

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Zhao Y, Burkow D, Song B. Mathematically modeling the role of triglyceride production on leptin resistance. In Patnaik S, Jain V, editors, Recent Developments in Intelligent Computing, Communication and Devices - Proceedings of ICCD 2017. Springer Verlag. 2019. p. 291-301. (Advances in Intelligent Systems and Computing). https://doi.org/10.1007/978-981-10-8944-2_35