Methylphenidate-induced conditioned taste aversions

An index of toxicity

Anthony L. Riley, Debra Zellner

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Following consumption of saccharin, groups of rats were injected with various doses of methylphenidate hydrochloride. Small aversions were found after one conditioning trial, with repeated saccharin-methlyphenidate pairings resulting in continued decrements in consumption. The strength of the aversion as well as the amount of individual variability were dose-related, with weaker aversions and greater individual variability occurring at the smaller dose (15 mg/kg). Although aversions were quite pronounced at higher doses, individual variability, although small, was still evident. The similarities and differences between methylphenidate-induced aversions and aversions based on emetics were discussed, along with the implications of these results as indices for methylphenidate-induced toxicity.

Original languageEnglish
Pages (from-to)354-358
Number of pages5
JournalPhysiological Psychology
Volume6
Issue number3
DOIs
StatePublished - 1 Jan 1978

Fingerprint

Methylphenidate
Saccharin
Emetics

Cite this

Riley, Anthony L. ; Zellner, Debra. / Methylphenidate-induced conditioned taste aversions : An index of toxicity. In: Physiological Psychology. 1978 ; Vol. 6, No. 3. pp. 354-358.
@article{2f249591785840309336f56ebe0a32fa,
title = "Methylphenidate-induced conditioned taste aversions: An index of toxicity",
abstract = "Following consumption of saccharin, groups of rats were injected with various doses of methylphenidate hydrochloride. Small aversions were found after one conditioning trial, with repeated saccharin-methlyphenidate pairings resulting in continued decrements in consumption. The strength of the aversion as well as the amount of individual variability were dose-related, with weaker aversions and greater individual variability occurring at the smaller dose (15 mg/kg). Although aversions were quite pronounced at higher doses, individual variability, although small, was still evident. The similarities and differences between methylphenidate-induced aversions and aversions based on emetics were discussed, along with the implications of these results as indices for methylphenidate-induced toxicity.",
author = "Riley, {Anthony L.} and Debra Zellner",
year = "1978",
month = "1",
day = "1",
doi = "10.3758/BF03326737",
language = "English",
volume = "6",
pages = "354--358",
journal = "Physiological Psychology",
issn = "0090-5046",
publisher = "Psychonomic Society Inc.",
number = "3",

}

Methylphenidate-induced conditioned taste aversions : An index of toxicity. / Riley, Anthony L.; Zellner, Debra.

In: Physiological Psychology, Vol. 6, No. 3, 01.01.1978, p. 354-358.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Methylphenidate-induced conditioned taste aversions

T2 - An index of toxicity

AU - Riley, Anthony L.

AU - Zellner, Debra

PY - 1978/1/1

Y1 - 1978/1/1

N2 - Following consumption of saccharin, groups of rats were injected with various doses of methylphenidate hydrochloride. Small aversions were found after one conditioning trial, with repeated saccharin-methlyphenidate pairings resulting in continued decrements in consumption. The strength of the aversion as well as the amount of individual variability were dose-related, with weaker aversions and greater individual variability occurring at the smaller dose (15 mg/kg). Although aversions were quite pronounced at higher doses, individual variability, although small, was still evident. The similarities and differences between methylphenidate-induced aversions and aversions based on emetics were discussed, along with the implications of these results as indices for methylphenidate-induced toxicity.

AB - Following consumption of saccharin, groups of rats were injected with various doses of methylphenidate hydrochloride. Small aversions were found after one conditioning trial, with repeated saccharin-methlyphenidate pairings resulting in continued decrements in consumption. The strength of the aversion as well as the amount of individual variability were dose-related, with weaker aversions and greater individual variability occurring at the smaller dose (15 mg/kg). Although aversions were quite pronounced at higher doses, individual variability, although small, was still evident. The similarities and differences between methylphenidate-induced aversions and aversions based on emetics were discussed, along with the implications of these results as indices for methylphenidate-induced toxicity.

UR - http://www.scopus.com/inward/record.url?scp=0018195339&partnerID=8YFLogxK

U2 - 10.3758/BF03326737

DO - 10.3758/BF03326737

M3 - Article

VL - 6

SP - 354

EP - 358

JO - Physiological Psychology

JF - Physiological Psychology

SN - 0090-5046

IS - 3

ER -