Methylphenidate-induced conditioned taste aversions: An index of toxicity

Anthony L. Riley, Debra Zellner

Research output: Contribution to journalArticle

12 Scopus citations


Following consumption of saccharin, groups of rats were injected with various doses of methylphenidate hydrochloride. Small aversions were found after one conditioning trial, with repeated saccharin-methlyphenidate pairings resulting in continued decrements in consumption. The strength of the aversion as well as the amount of individual variability were dose-related, with weaker aversions and greater individual variability occurring at the smaller dose (15 mg/kg). Although aversions were quite pronounced at higher doses, individual variability, although small, was still evident. The similarities and differences between methylphenidate-induced aversions and aversions based on emetics were discussed, along with the implications of these results as indices for methylphenidate-induced toxicity.

Original languageEnglish
Pages (from-to)354-358
Number of pages5
JournalPhysiological Psychology
Issue number3
StatePublished - 1 Jan 1978

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