Microbial metabolites of ophiobolin a and antimicrobial evaluation of ophiobolins

Erguang Li, Alice M. Clark, David Rotella, Charles D. Hufford, David P. Rotella

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Ophiobolin A [1], 3-anhydroophiobolin A [2], ophiobolin B [3], and ophiobolin L [4] were isolated from fermentation broths ofCochliobolus heterostrophus. Preliminary screening showed that a number of organisms were capable of metabolizing the sesterterpene ophiobolin A [1]. Large-scale transformations of ophiobolin A [1] with Polyangium cellulosum produced 6 and 7 while Pseudomonas aeruginosa produced 8. Resting-cell preparations of Penicillium patulum afforded 9 and 10. The structures of these metabolites were established by spectroscopic methods and by comparison of the spectral data with those of the starting material. The antimicrobial activity of the ophiobolins was also evaluated.

Original languageEnglish
Pages (from-to)74-81
Number of pages8
JournalJournal of Natural Products
Volume58
Issue number1
DOIs
StatePublished - 1 Jan 1995

Fingerprint

Metabolites
Sesterterpenes
Myxococcales
Penicillium
Fermentation
Pseudomonas aeruginosa
Screening
ophiobolin A
ophiobolins

Cite this

Li, Erguang ; Clark, Alice M. ; Rotella, David ; Hufford, Charles D. ; Rotella, David P. / Microbial metabolites of ophiobolin a and antimicrobial evaluation of ophiobolins. In: Journal of Natural Products. 1995 ; Vol. 58, No. 1. pp. 74-81.
@article{f2fd6b633bac4afd9b7afd8f7e156df4,
title = "Microbial metabolites of ophiobolin a and antimicrobial evaluation of ophiobolins",
abstract = "Ophiobolin A [1], 3-anhydroophiobolin A [2], ophiobolin B [3], and ophiobolin L [4] were isolated from fermentation broths ofCochliobolus heterostrophus. Preliminary screening showed that a number of organisms were capable of metabolizing the sesterterpene ophiobolin A [1]. Large-scale transformations of ophiobolin A [1] with Polyangium cellulosum produced 6 and 7 while Pseudomonas aeruginosa produced 8. Resting-cell preparations of Penicillium patulum afforded 9 and 10. The structures of these metabolites were established by spectroscopic methods and by comparison of the spectral data with those of the starting material. The antimicrobial activity of the ophiobolins was also evaluated.",
author = "Erguang Li and Clark, {Alice M.} and David Rotella and Hufford, {Charles D.} and Rotella, {David P.}",
year = "1995",
month = "1",
day = "1",
doi = "10.1021/np50115a009",
language = "English",
volume = "58",
pages = "74--81",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "1",

}

Microbial metabolites of ophiobolin a and antimicrobial evaluation of ophiobolins. / Li, Erguang; Clark, Alice M.; Rotella, David; Hufford, Charles D.; Rotella, David P.

In: Journal of Natural Products, Vol. 58, No. 1, 01.01.1995, p. 74-81.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Microbial metabolites of ophiobolin a and antimicrobial evaluation of ophiobolins

AU - Li, Erguang

AU - Clark, Alice M.

AU - Rotella, David

AU - Hufford, Charles D.

AU - Rotella, David P.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Ophiobolin A [1], 3-anhydroophiobolin A [2], ophiobolin B [3], and ophiobolin L [4] were isolated from fermentation broths ofCochliobolus heterostrophus. Preliminary screening showed that a number of organisms were capable of metabolizing the sesterterpene ophiobolin A [1]. Large-scale transformations of ophiobolin A [1] with Polyangium cellulosum produced 6 and 7 while Pseudomonas aeruginosa produced 8. Resting-cell preparations of Penicillium patulum afforded 9 and 10. The structures of these metabolites were established by spectroscopic methods and by comparison of the spectral data with those of the starting material. The antimicrobial activity of the ophiobolins was also evaluated.

AB - Ophiobolin A [1], 3-anhydroophiobolin A [2], ophiobolin B [3], and ophiobolin L [4] were isolated from fermentation broths ofCochliobolus heterostrophus. Preliminary screening showed that a number of organisms were capable of metabolizing the sesterterpene ophiobolin A [1]. Large-scale transformations of ophiobolin A [1] with Polyangium cellulosum produced 6 and 7 while Pseudomonas aeruginosa produced 8. Resting-cell preparations of Penicillium patulum afforded 9 and 10. The structures of these metabolites were established by spectroscopic methods and by comparison of the spectral data with those of the starting material. The antimicrobial activity of the ophiobolins was also evaluated.

UR - http://www.scopus.com/inward/record.url?scp=0028952229&partnerID=8YFLogxK

U2 - 10.1021/np50115a009

DO - 10.1021/np50115a009

M3 - Article

C2 - 7760080

AN - SCOPUS:0028952229

VL - 58

SP - 74

EP - 81

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 1

ER -