Microbial metabolites of ophiobolin a and antimicrobial evaluation of ophiobolins

Erguang Li, Alice M. Clark, David P. Rotella, Charles D. Hufford, David P. Rotella

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Ophiobolin A [1], 3-anhydroophiobolin A [2], ophiobolin B [3], and ophiobolin L [4] were isolated from fermentation broths ofCochliobolus heterostrophus. Preliminary screening showed that a number of organisms were capable of metabolizing the sesterterpene ophiobolin A [1]. Large-scale transformations of ophiobolin A [1] with Polyangium cellulosum produced 6 and 7 while Pseudomonas aeruginosa produced 8. Resting-cell preparations of Penicillium patulum afforded 9 and 10. The structures of these metabolites were established by spectroscopic methods and by comparison of the spectral data with those of the starting material. The antimicrobial activity of the ophiobolins was also evaluated.

Original languageEnglish
Pages (from-to)74-81
Number of pages8
JournalJournal of Natural Products
Volume58
Issue number1
DOIs
StatePublished - 1 Jan 1995

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