Mono- and Di-2,2,2-trichloroethyl Acetals as Protecting Groups

John Isidor, Robert M. Carlson

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Abstract

Mono- and di-2,2,2-trichloroethyl acetals have been selectively prepared in good yields by acid-catalyzed alcohol exchange with 2,2,2-trichloroethanol and dimethyl or diethyl acetals. A nonacidic and aprotic reductive cleavage using activated zinc dust in ethyl acetate or THE regenerates the carbonyl.

Original languageEnglish
Pages (from-to)554-556
Number of pages3
JournalJournal of Organic Chemistry
Volume38
Issue number3
DOIs
StatePublished - 1 Feb 1973

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Acetals
Dust
Zinc
Alcohols
Acids
2,2,2-trichloroethanol
ethyl acetate

Cite this

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abstract = "Mono- and di-2,2,2-trichloroethyl acetals have been selectively prepared in good yields by acid-catalyzed alcohol exchange with 2,2,2-trichloroethanol and dimethyl or diethyl acetals. A nonacidic and aprotic reductive cleavage using activated zinc dust in ethyl acetate or THE regenerates the carbonyl.",
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Mono- and Di-2,2,2-trichloroethyl Acetals as Protecting Groups. / Isidor, John; Carlson, Robert M.

In: Journal of Organic Chemistry, Vol. 38, No. 3, 01.02.1973, p. 554-556.

Research output: Contribution to journalArticleResearchpeer-review

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AB - Mono- and di-2,2,2-trichloroethyl acetals have been selectively prepared in good yields by acid-catalyzed alcohol exchange with 2,2,2-trichloroethanol and dimethyl or diethyl acetals. A nonacidic and aprotic reductive cleavage using activated zinc dust in ethyl acetate or THE regenerates the carbonyl.

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