Mono- and Di-2,2,2-trichloroethyl Acetals as Protecting Groups

John L. Isidor, Robert M. Carlson

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Mono- and di-2,2,2-trichloroethyl acetals have been selectively prepared in good yields by acid-catalyzed alcohol exchange with 2,2,2-trichloroethanol and dimethyl or diethyl acetals. A nonacidic and aprotic reductive cleavage using activated zinc dust in ethyl acetate or THE regenerates the carbonyl.

Original languageEnglish
Pages (from-to)554-556
Number of pages3
JournalJournal of Organic Chemistry
Issue number3
StatePublished - 1 Feb 1973


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