Natural product analogues

Towards a blueprint for analogue-focused synthesis

Research output: Contribution to journalReview articleResearchpeer-review

20 Citations (Scopus)

Abstract

For the first time a general overview of approaches to the synthesis of natural product analogues is presented. This reflects a process of evolution of natural product synthesis which has accelerated in the years since the implementation of diversity-oriented synthesis, which has emerged in parallel with collective synthesis, diverted total synthesis and the preparation of truncated natural products optimised for biological activity. A method involving computational assessment for the validation of core-modified natural product analogues is discussed.

Original languageEnglish
Pages (from-to)5059-5109
Number of pages51
JournalChemical Society Reviews
Volume46
Issue number16
DOIs
StatePublished - 21 Aug 2017

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abstract = "For the first time a general overview of approaches to the synthesis of natural product analogues is presented. This reflects a process of evolution of natural product synthesis which has accelerated in the years since the implementation of diversity-oriented synthesis, which has emerged in parallel with collective synthesis, diverted total synthesis and the preparation of truncated natural products optimised for biological activity. A method involving computational assessment for the validation of core-modified natural product analogues is discussed.",
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Natural product analogues : Towards a blueprint for analogue-focused synthesis. / Bebbington, Magnus.

In: Chemical Society Reviews, Vol. 46, No. 16, 21.08.2017, p. 5059-5109.

Research output: Contribution to journalReview articleResearchpeer-review

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