Natural product analogues: Towards a blueprint for analogue-focused synthesis

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For the first time a general overview of approaches to the synthesis of natural product analogues is presented. This reflects a process of evolution of natural product synthesis which has accelerated in the years since the implementation of diversity-oriented synthesis, which has emerged in parallel with collective synthesis, diverted total synthesis and the preparation of truncated natural products optimised for biological activity. A method involving computational assessment for the validation of core-modified natural product analogues is discussed.

Original languageEnglish
Pages (from-to)5059-5109
Number of pages51
JournalChemical Society Reviews
Issue number16
StatePublished - 21 Aug 2017


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