Opiate withdrawal: The result of conditioning or physiological mechanisms?

Debra A. Zellner, Robert J. Dacanay, Anthony L. Riley

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Although it has been suggested that opiate withdrawal responses might be conditioned compensatory responses elicited by drug-associated stimuli, the present results do not support such a view. Withdrawal, as measured by an aversion to a saccharin solution following the termination of morphine administration, occured independent of the presence of morphine-paired environmental or temporal cues. These results suggest that withdrawal is most likely the result of some physiological mechanism, rather than the result of conditioning.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Issue number2
StatePublished - Feb 1984


  • Aversions
  • Compensatory classical conditioning
  • Withdrawal


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