Phosphodiesterase 5 inhibitors: Current status and potential applications

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Abstract

Phosphodiesterase enzymes convert cyclic GMP and cyclic AMP to the corresponding nucleotide monophosphates. Phosphodiesterase 5 (PDE5) inhibition is now a widely accepted and efficacious therapeutic option for the treatment of erectile dysfunction in men, as a result of extensive clinical experience with sildenafil and other new PDE5 inhibitors. Research in the field continues at a substantial level to identify new, selective PDE5 inhibitors and to investigate their usefulness and activity in other areas. This review summarizes recent clinical trials with PDE5 inhibitors, advances in medicinal chemistry, and other activities and potential applications of this class of compounds.

Original languageEnglish
Pages (from-to)674-682
Number of pages9
JournalNature Reviews Drug Discovery
Volume1
Issue number9
DOIs
StatePublished - 1 Sep 2002

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