Potent inhibitors of the MAP kinase p38

James R. Henry, Kenneth C. Rupert, John H. Dodd, Ignatius J. Turchi, Scott A. Wadsworth, Druie E. Cavender, Peter H. Schafer, John J. Siekierka

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

Original languageEnglish
Pages (from-to)3335-3340
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number23
StatePublished - 1 Dec 1998


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