Potent inhibitors of the MAP kinase p38

James R. Henry, Kenneth C. Rupert, John H. Dodd, Ignatius J. Turchi, Scott A. Wadsworth, Druie E. Cavender, Peter H. Schafer, John Siekierka

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Abstract

The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

Original languageEnglish
Pages (from-to)3335-3340
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number23
DOIs
StatePublished - 1 Dec 1998

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p38 Mitogen-Activated Protein Kinases
Interleukin-1
Inflammatory Bowel Diseases
Rheumatoid Arthritis
Cytokines
Biosynthesis

Cite this

Henry, J. R., Rupert, K. C., Dodd, J. H., Turchi, I. J., Wadsworth, S. A., Cavender, D. E., ... Siekierka, J. (1998). Potent inhibitors of the MAP kinase p38. Bioorganic and Medicinal Chemistry Letters, 8(23), 3335-3340. https://doi.org/10.1016/S0960-894X(98)00589-7
Henry, James R. ; Rupert, Kenneth C. ; Dodd, John H. ; Turchi, Ignatius J. ; Wadsworth, Scott A. ; Cavender, Druie E. ; Schafer, Peter H. ; Siekierka, John. / Potent inhibitors of the MAP kinase p38. In: Bioorganic and Medicinal Chemistry Letters. 1998 ; Vol. 8, No. 23. pp. 3335-3340.
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Henry, JR, Rupert, KC, Dodd, JH, Turchi, IJ, Wadsworth, SA, Cavender, DE, Schafer, PH & Siekierka, J 1998, 'Potent inhibitors of the MAP kinase p38', Bioorganic and Medicinal Chemistry Letters, vol. 8, no. 23, pp. 3335-3340. https://doi.org/10.1016/S0960-894X(98)00589-7

Potent inhibitors of the MAP kinase p38. / Henry, James R.; Rupert, Kenneth C.; Dodd, John H.; Turchi, Ignatius J.; Wadsworth, Scott A.; Cavender, Druie E.; Schafer, Peter H.; Siekierka, John.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 8, No. 23, 01.12.1998, p. 3335-3340.

Research output: Contribution to journalArticleResearchpeer-review

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Henry JR, Rupert KC, Dodd JH, Turchi IJ, Wadsworth SA, Cavender DE et al. Potent inhibitors of the MAP kinase p38. Bioorganic and Medicinal Chemistry Letters. 1998 Dec 1;8(23):3335-3340. https://doi.org/10.1016/S0960-894X(98)00589-7