Potent inhibitors of the MAP kinase p38

James R. Henry; Kenneth C. Rupert; John H. Dodd; Ignatius J. Turchi; Scott A. Wadsworth; Druie E. Cavender; Peter H. Schafer; John J. Siekierka

doi:10.1016/S0960-894X(98)00589-7

Potent inhibitors of the MAP kinase p38

James R. Henry, Kenneth C. Rupert, John H. Dodd, Ignatius J. Turchi, Scott A. Wadsworth, Druie E. Cavender, Peter H. Schafer, John J. Siekierka

Chemistry and Biochemistry

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Abstract

The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

Original language	English
Pages (from-to)	3335-3340
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(98)00589-7
State	Published - 1 Dec 1998

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title = "Potent inhibitors of the MAP kinase p38",

abstract = "The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.",

author = "Henry, {James R.} and Rupert, {Kenneth C.} and Dodd, {John H.} and Turchi, {Ignatius J.} and Wadsworth, {Scott A.} and Cavender, {Druie E.} and Schafer, {Peter H.} and Siekierka, {John J.}",

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AU - Henry, James R.

AU - Rupert, Kenneth C.

AU - Dodd, John H.

AU - Turchi, Ignatius J.

AU - Wadsworth, Scott A.

AU - Cavender, Druie E.

AU - Schafer, Peter H.

AU - Siekierka, John J.

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JO - Bioorganic and Medicinal Chemistry Letters

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ER -

Potent inhibitors of the MAP kinase p38

Abstract

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