Potent inhibitors of the MAP kinase p38

James R. Henry; Kenneth C. Rupert; John H. Dodd; Ignatius J. Turchi; Scott A. Wadsworth; Druie E. Cavender; Peter H. Schafer; John J. Siekierka

doi:10.1016/S0960-894X(98)00589-7

Potent inhibitors of the MAP kinase p38

James R. Henry
, Kenneth C. Rupert
, John H. Dodd
, Ignatius J. Turchi
, Scott A. Wadsworth
, Druie E. Cavender
, Peter H. Schafer
, John J. Siekierka

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

Original language	English
Pages (from-to)	3335-3340
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(98)00589-7
State	Published - 1 Dec 1998

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title = "Potent inhibitors of the MAP kinase p38",

abstract = "The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.",

author = "Henry, \{James R.\} and Rupert, \{Kenneth C.\} and Dodd, \{John H.\} and Turchi, \{Ignatius J.\} and Wadsworth, \{Scott A.\} and Cavender, \{Druie E.\} and Schafer, \{Peter H.\} and Siekierka, \{John J.\}",

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AU - Henry, James R.

AU - Rupert, Kenneth C.

AU - Dodd, John H.

AU - Turchi, Ignatius J.

AU - Wadsworth, Scott A.

AU - Cavender, Druie E.

AU - Schafer, Peter H.

AU - Siekierka, John J.

PY - 1998/12/1

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N2 - The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

AB - The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

UR - https://www.scopus.com/pages/publications/0032401112

U2 - 10.1016/S0960-894X(98)00589-7

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VL - 8

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EP - 3340

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Potent inhibitors of the MAP kinase p38

Abstract

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