Abstract
In addition to their clinical utility in tissue transplantation the immunosuppressive agents FK-506 (Prograf) and rapamycin, have proven to be valuable tools for gaining insight into the biochemistry of T-cell activation. The findings that the protein phosphatase calcineurin and cell cycle control are key elements in T-cell activation and proliferation are the direct result of investigations into the mechanism of action of FK-506 and rapamycin and provide potentially novel therapeutic targets.
Original language | English |
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Pages (from-to) | 110-116 |
Number of pages | 7 |
Journal | Immunologic Research |
Volume | 13 |
Issue number | 2-3 |
DOIs | |
State | Published - Jun 1994 |
Keywords
- Cell cycle
- Immunophilins
- Immunosuppression
- T-cell activation