Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In addition to their clinical utility in tissue transplantation the immunosuppressive agents FK-506 (Prograf) and rapamycin, have proven to be valuable tools for gaining insight into the biochemistry of T-cell activation. The findings that the protein phosphatase calcineurin and cell cycle control are key elements in T-cell activation and proliferation are the direct result of investigations into the mechanism of action of FK-506 and rapamycin and provide potentially novel therapeutic targets.

Original languageEnglish
Pages (from-to)110-116
Number of pages7
JournalImmunologic Research
Volume13
Issue number2-3
DOIs
StatePublished - 1 Jun 1994

Fingerprint

Tacrolimus
Sirolimus
Immunosuppressive Agents
Signal Transduction
T-Lymphocytes
Pharmaceutical Preparations
Tissue Transplantation
Calcineurin
Phosphoprotein Phosphatases
Cell Cycle Checkpoints
Biochemistry
Cell Proliferation
Therapeutics

Keywords

  • Cell cycle
  • Immunophilins
  • Immunosuppression
  • T-cell activation

Cite this

@article{7b11ed75fb3f458d89702d93459c47bb,
title = "Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin",
abstract = "In addition to their clinical utility in tissue transplantation the immunosuppressive agents FK-506 (Prograf) and rapamycin, have proven to be valuable tools for gaining insight into the biochemistry of T-cell activation. The findings that the protein phosphatase calcineurin and cell cycle control are key elements in T-cell activation and proliferation are the direct result of investigations into the mechanism of action of FK-506 and rapamycin and provide potentially novel therapeutic targets.",
keywords = "Cell cycle, Immunophilins, Immunosuppression, T-cell activation",
author = "John Siekierka",
year = "1994",
month = "6",
day = "1",
doi = "10.1007/BF02918272",
language = "English",
volume = "13",
pages = "110--116",
journal = "Immunologic Research",
issn = "0257-277X",
publisher = "Humana Press",
number = "2-3",

}

Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin. / Siekierka, John.

In: Immunologic Research, Vol. 13, No. 2-3, 01.06.1994, p. 110-116.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin

AU - Siekierka, John

PY - 1994/6/1

Y1 - 1994/6/1

N2 - In addition to their clinical utility in tissue transplantation the immunosuppressive agents FK-506 (Prograf) and rapamycin, have proven to be valuable tools for gaining insight into the biochemistry of T-cell activation. The findings that the protein phosphatase calcineurin and cell cycle control are key elements in T-cell activation and proliferation are the direct result of investigations into the mechanism of action of FK-506 and rapamycin and provide potentially novel therapeutic targets.

AB - In addition to their clinical utility in tissue transplantation the immunosuppressive agents FK-506 (Prograf) and rapamycin, have proven to be valuable tools for gaining insight into the biochemistry of T-cell activation. The findings that the protein phosphatase calcineurin and cell cycle control are key elements in T-cell activation and proliferation are the direct result of investigations into the mechanism of action of FK-506 and rapamycin and provide potentially novel therapeutic targets.

KW - Cell cycle

KW - Immunophilins

KW - Immunosuppression

KW - T-cell activation

UR - http://www.scopus.com/inward/record.url?scp=0028618606&partnerID=8YFLogxK

U2 - 10.1007/BF02918272

DO - 10.1007/BF02918272

M3 - Article

C2 - 7539823

AN - SCOPUS:0028618606

VL - 13

SP - 110

EP - 116

JO - Immunologic Research

JF - Immunologic Research

SN - 0257-277X

IS - 2-3

ER -