Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin

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In addition to their clinical utility in tissue transplantation the immunosuppressive agents FK-506 (Prograf) and rapamycin, have proven to be valuable tools for gaining insight into the biochemistry of T-cell activation. The findings that the protein phosphatase calcineurin and cell cycle control are key elements in T-cell activation and proliferation are the direct result of investigations into the mechanism of action of FK-506 and rapamycin and provide potentially novel therapeutic targets.

Original languageEnglish
Pages (from-to)110-116
Number of pages7
JournalImmunologic Research
Issue number2-3
Publication statusPublished - 1 Jun 1994



  • Cell cycle
  • Immunophilins
  • Immunosuppression
  • T-cell activation

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