Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors

Rohit Bhat, Sreedhar R. Tummalapalli, David Rotella

Research output: Contribution to journalReview articleResearchpeer-review

69 Citations (Scopus)

Abstract

The discovery and clinical development of heat shock protein 90 (Hsp90) inhibitors continue to progress. A number of Hsp90 inhibitors are in clinical trials, and preclinical discoveries of new chemotypes that bind to distinct regions in the protein as well as isoform selective compounds are active areas of research. This review will highlight progress in the field since 2010.

Original languageEnglish
Pages (from-to)8718-8728
Number of pages11
JournalJournal of Medicinal Chemistry
Volume57
Issue number21
DOIs
StatePublished - 13 Nov 2014

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HSP90 Heat-Shock Proteins
Protein Isoforms
Clinical Trials
Research
Proteins

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Bhat, Rohit ; Tummalapalli, Sreedhar R. ; Rotella, David. / Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors. In: Journal of Medicinal Chemistry. 2014 ; Vol. 57, No. 21. pp. 8718-8728.
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Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors. / Bhat, Rohit; Tummalapalli, Sreedhar R.; Rotella, David.

In: Journal of Medicinal Chemistry, Vol. 57, No. 21, 13.11.2014, p. 8718-8728.

Research output: Contribution to journalReview articleResearchpeer-review

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