Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors

Rohit Bhat; Sreedhar R. Tummalapalli; David P. Rotella

doi:10.1021/jm500823a

Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors

Rohit Bhat, Sreedhar R. Tummalapalli, David P. Rotella

Chemistry and Biochemistry

Research output: Contribution to journal › Review article › peer-review

115 Scopus citations

Abstract

The discovery and clinical development of heat shock protein 90 (Hsp90) inhibitors continue to progress. A number of Hsp90 inhibitors are in clinical trials, and preclinical discoveries of new chemotypes that bind to distinct regions in the protein as well as isoform selective compounds are active areas of research. This review will highlight progress in the field since 2010.

Original language	English
Pages (from-to)	8718-8728
Number of pages	11
Journal	Journal of Medicinal Chemistry
Volume	57
Issue number	21
DOIs	https://doi.org/10.1021/jm500823a
State	Published - 13 Nov 2014

Access to Document

10.1021/jm500823a

Cite this

@article{111ade2850ce4670a95e9b7ccb5838e2,

title = "Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors",

abstract = "The discovery and clinical development of heat shock protein 90 (Hsp90) inhibitors continue to progress. A number of Hsp90 inhibitors are in clinical trials, and preclinical discoveries of new chemotypes that bind to distinct regions in the protein as well as isoform selective compounds are active areas of research. This review will highlight progress in the field since 2010.",

author = "Rohit Bhat and Tummalapalli, {Sreedhar R.} and Rotella, {David P.}",

note = "Publisher Copyright: {\textcopyright} 2014 American Chemical Society.",

year = "2014",

month = nov,

day = "13",

doi = "10.1021/jm500823a",

language = "English",

volume = "57",

pages = "8718--8728",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "21",

}

TY - JOUR

T1 - Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors

AU - Bhat, Rohit

AU - Tummalapalli, Sreedhar R.

AU - Rotella, David P.

PY - 2014/11/13

Y1 - 2014/11/13

N2 - The discovery and clinical development of heat shock protein 90 (Hsp90) inhibitors continue to progress. A number of Hsp90 inhibitors are in clinical trials, and preclinical discoveries of new chemotypes that bind to distinct regions in the protein as well as isoform selective compounds are active areas of research. This review will highlight progress in the field since 2010.

AB - The discovery and clinical development of heat shock protein 90 (Hsp90) inhibitors continue to progress. A number of Hsp90 inhibitors are in clinical trials, and preclinical discoveries of new chemotypes that bind to distinct regions in the protein as well as isoform selective compounds are active areas of research. This review will highlight progress in the field since 2010.

UR - http://www.scopus.com/inward/record.url?scp=84921687193&partnerID=8YFLogxK

U2 - 10.1021/jm500823a

DO - 10.1021/jm500823a

M3 - Review article

C2 - 25141341

AN - SCOPUS:84921687193

SN - 0022-2623

VL - 57

SP - 8718

EP - 8728

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 21

ER -

Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors

Abstract

Access to Document

Other files and links

Fingerprint

Cite this