We report the Raman spectrum of single crystals of Bi2.2Ca0. 8Sr2Cu2O8+δ. The most prominent features are at 120, 295, 462, and 625 cm-1. The 462-cm-1 mode is tentatively assigned to axial O(3) symmetric stretching. The 625-cm-1 mode is assigned to planar Cu-O(1) bond stretching. The 120-cm-1 mode shows a strong a-b anisotropy. The effect of the b-axis superstructure upon the Raman spectrum is emphasized.