Rapid onset pressor response to exercise in young women with a family history of hypertension

Evan Matthews, Jody L. Greaney, Megan M. Wenner

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

New Findings: What is the central question of this study? Alterations in blood pressure control at exercise onset are apparent in older adults with established cardiovascular disease. It is currently not known whether these alterations are evident in young adults with a family history of hypertension. What is the main finding and its importance? We demonstrate that young women with a family history of hypertension display a larger change in blood pressure within the first 10 s of isometric exercise. These data suggest altered blood pressure control in young women with a family history of hypertension. Hypertensive adults demonstrate atypical increases in blood pressure (BP) and muscle sympathetic nerve activity (MSNA) at the immediate onset of static muscle contraction. However, it is unknown whether these abnormal responses occur in young, otherwise healthy adults at risk for developing future disease, such as those with a family history of hypertension (+FH). We tested the hypothesis that +FH young women have exaggerated increases in BP and MSNA at the onset of static muscle contraction compared with those without a family history of hypertension (−FH). We retrospectively examined beat-by-beat BP and MSNA during the initial 30 s of isometric handgrip exercise (30% of maximal voluntary contraction) in 16 +FH (22 ± 2 years old, 22 ± 3 kg m−2) and 16 −FH (22 ± 3 years old, 22 ± 3 kg m−2) women. Resting mean arterial pressure (+FH 80 ± 11 mmHg versus −FH 84 ± 13 mmHg), MSNA burst frequency (+FH 7 ± 3 bursts min−1 versus −FH 9 ± 5 bursts min−1) and burst incidence [+FH 12 ± 4 bursts (100 heart beats)−1 versus −FH 12 ± 8 bursts (100 heart beats)−1] were similar between groups (all P > 0.05). Within the first 10 s of exercise, changes in mean arterial pressure (+FH Δ8 ± 6 mmHg versus −FH Δ3 ± 2 mmHg, P < 0.05) and heart rate (+FH Δ8 ± 5 beats min−1 versus −FH Δ4 ± 4 beats min−1, P < 0.05) were greater in +FH women. Absolute MSNA burst frequency during the first 30 s of exercise was not different between groups (−FH 7 ± 5 bursts min−1 versus +FH 9 ± 3 bursts min−1). Cardiovascular and sympathetic responses during the cold pressor test were not different between groups. These data demonstrate that young women at risk for developing cardiovascular disease exhibit greater changes in BP at the onset of static muscle contraction.

Original languageEnglish
Pages (from-to)1092-1099
Number of pages8
JournalExperimental Physiology
Volume102
Issue number9
DOIs
StatePublished - 1 Sep 2017

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Exercise
Hypertension
Blood Pressure
Muscles
Muscle Contraction
Arterial Pressure
Cardiovascular Diseases
Young Adult

Keywords

  • blood pressure
  • handgrip exercise
  • muscle sympathetic nerve activity

Cite this

Matthews, Evan ; Greaney, Jody L. ; Wenner, Megan M. / Rapid onset pressor response to exercise in young women with a family history of hypertension. In: Experimental Physiology. 2017 ; Vol. 102, No. 9. pp. 1092-1099.
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abstract = "New Findings: What is the central question of this study? Alterations in blood pressure control at exercise onset are apparent in older adults with established cardiovascular disease. It is currently not known whether these alterations are evident in young adults with a family history of hypertension. What is the main finding and its importance? We demonstrate that young women with a family history of hypertension display a larger change in blood pressure within the first 10 s of isometric exercise. These data suggest altered blood pressure control in young women with a family history of hypertension. Hypertensive adults demonstrate atypical increases in blood pressure (BP) and muscle sympathetic nerve activity (MSNA) at the immediate onset of static muscle contraction. However, it is unknown whether these abnormal responses occur in young, otherwise healthy adults at risk for developing future disease, such as those with a family history of hypertension (+FH). We tested the hypothesis that +FH young women have exaggerated increases in BP and MSNA at the onset of static muscle contraction compared with those without a family history of hypertension (−FH). We retrospectively examined beat-by-beat BP and MSNA during the initial 30 s of isometric handgrip exercise (30{\%} of maximal voluntary contraction) in 16 +FH (22 ± 2 years old, 22 ± 3 kg m−2) and 16 −FH (22 ± 3 years old, 22 ± 3 kg m−2) women. Resting mean arterial pressure (+FH 80 ± 11 mmHg versus −FH 84 ± 13 mmHg), MSNA burst frequency (+FH 7 ± 3 bursts min−1 versus −FH 9 ± 5 bursts min−1) and burst incidence [+FH 12 ± 4 bursts (100 heart beats)−1 versus −FH 12 ± 8 bursts (100 heart beats)−1] were similar between groups (all P > 0.05). Within the first 10 s of exercise, changes in mean arterial pressure (+FH Δ8 ± 6 mmHg versus −FH Δ3 ± 2 mmHg, P < 0.05) and heart rate (+FH Δ8 ± 5 beats min−1 versus −FH Δ4 ± 4 beats min−1, P < 0.05) were greater in +FH women. Absolute MSNA burst frequency during the first 30 s of exercise was not different between groups (−FH 7 ± 5 bursts min−1 versus +FH 9 ± 3 bursts min−1). Cardiovascular and sympathetic responses during the cold pressor test were not different between groups. These data demonstrate that young women at risk for developing cardiovascular disease exhibit greater changes in BP at the onset of static muscle contraction.",
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Rapid onset pressor response to exercise in young women with a family history of hypertension. / Matthews, Evan; Greaney, Jody L.; Wenner, Megan M.

In: Experimental Physiology, Vol. 102, No. 9, 01.09.2017, p. 1092-1099.

Research output: Contribution to journalArticleResearchpeer-review

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AB - New Findings: What is the central question of this study? Alterations in blood pressure control at exercise onset are apparent in older adults with established cardiovascular disease. It is currently not known whether these alterations are evident in young adults with a family history of hypertension. What is the main finding and its importance? We demonstrate that young women with a family history of hypertension display a larger change in blood pressure within the first 10 s of isometric exercise. These data suggest altered blood pressure control in young women with a family history of hypertension. Hypertensive adults demonstrate atypical increases in blood pressure (BP) and muscle sympathetic nerve activity (MSNA) at the immediate onset of static muscle contraction. However, it is unknown whether these abnormal responses occur in young, otherwise healthy adults at risk for developing future disease, such as those with a family history of hypertension (+FH). We tested the hypothesis that +FH young women have exaggerated increases in BP and MSNA at the onset of static muscle contraction compared with those without a family history of hypertension (−FH). We retrospectively examined beat-by-beat BP and MSNA during the initial 30 s of isometric handgrip exercise (30% of maximal voluntary contraction) in 16 +FH (22 ± 2 years old, 22 ± 3 kg m−2) and 16 −FH (22 ± 3 years old, 22 ± 3 kg m−2) women. Resting mean arterial pressure (+FH 80 ± 11 mmHg versus −FH 84 ± 13 mmHg), MSNA burst frequency (+FH 7 ± 3 bursts min−1 versus −FH 9 ± 5 bursts min−1) and burst incidence [+FH 12 ± 4 bursts (100 heart beats)−1 versus −FH 12 ± 8 bursts (100 heart beats)−1] were similar between groups (all P > 0.05). Within the first 10 s of exercise, changes in mean arterial pressure (+FH Δ8 ± 6 mmHg versus −FH Δ3 ± 2 mmHg, P < 0.05) and heart rate (+FH Δ8 ± 5 beats min−1 versus −FH Δ4 ± 4 beats min−1, P < 0.05) were greater in +FH women. Absolute MSNA burst frequency during the first 30 s of exercise was not different between groups (−FH 7 ± 5 bursts min−1 versus +FH 9 ± 3 bursts min−1). Cardiovascular and sympathetic responses during the cold pressor test were not different between groups. These data demonstrate that young women at risk for developing cardiovascular disease exhibit greater changes in BP at the onset of static muscle contraction.

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