Rats learn to like the taste of morphine

Debra Zellner, K. C. Berridge, H. J. Grill, J. W. Ternes

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

When rats are forced to drink a morphine solution as their only source of fluid, they eventually reverse their initial preference and drink more morphine than water in a two-bottle preference test. The cause of this shift in preference was examined with the taste reactivity test which involves the analysis of fixed action patterns elicited by taste solutions infused into rats' mouths. Three morphine concentrations and two levels of motivation were studied. A greater percentage of ingestive taste reactivity responses occurred to the oral morphine infusion in morphine-raised rats than in water-raised rats. These data argue against the idea that enhanced morphine ingestion is caused by anticipation of positive consequences. Instead, they support the idea that rats come to 'like' the flavor of the morphine solution; in other words, the palatability evaluation of the morphine changes, possibly through an association between the flavor and the hedonically positive effects of the morphine.

Original languageEnglish
Pages (from-to)290-300
Number of pages11
JournalBehavioral Neuroscience
Volume99
Issue number2
DOIs
StatePublished - 1 Jan 1985

Fingerprint

Morphine
Instinct
Water
Mouth
Motivation
Eating

Cite this

Zellner, D., Berridge, K. C., Grill, H. J., & Ternes, J. W. (1985). Rats learn to like the taste of morphine. Behavioral Neuroscience, 99(2), 290-300. https://doi.org/10.1037/0735-7044.99.2.290
Zellner, Debra ; Berridge, K. C. ; Grill, H. J. ; Ternes, J. W. / Rats learn to like the taste of morphine. In: Behavioral Neuroscience. 1985 ; Vol. 99, No. 2. pp. 290-300.
@article{f64a0299610543c8a94b2d897a438527,
title = "Rats learn to like the taste of morphine",
abstract = "When rats are forced to drink a morphine solution as their only source of fluid, they eventually reverse their initial preference and drink more morphine than water in a two-bottle preference test. The cause of this shift in preference was examined with the taste reactivity test which involves the analysis of fixed action patterns elicited by taste solutions infused into rats' mouths. Three morphine concentrations and two levels of motivation were studied. A greater percentage of ingestive taste reactivity responses occurred to the oral morphine infusion in morphine-raised rats than in water-raised rats. These data argue against the idea that enhanced morphine ingestion is caused by anticipation of positive consequences. Instead, they support the idea that rats come to 'like' the flavor of the morphine solution; in other words, the palatability evaluation of the morphine changes, possibly through an association between the flavor and the hedonically positive effects of the morphine.",
author = "Debra Zellner and Berridge, {K. C.} and Grill, {H. J.} and Ternes, {J. W.}",
year = "1985",
month = "1",
day = "1",
doi = "10.1037/0735-7044.99.2.290",
language = "English",
volume = "99",
pages = "290--300",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association Inc.",
number = "2",

}

Zellner, D, Berridge, KC, Grill, HJ & Ternes, JW 1985, 'Rats learn to like the taste of morphine', Behavioral Neuroscience, vol. 99, no. 2, pp. 290-300. https://doi.org/10.1037/0735-7044.99.2.290

Rats learn to like the taste of morphine. / Zellner, Debra; Berridge, K. C.; Grill, H. J.; Ternes, J. W.

In: Behavioral Neuroscience, Vol. 99, No. 2, 01.01.1985, p. 290-300.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Rats learn to like the taste of morphine

AU - Zellner, Debra

AU - Berridge, K. C.

AU - Grill, H. J.

AU - Ternes, J. W.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - When rats are forced to drink a morphine solution as their only source of fluid, they eventually reverse their initial preference and drink more morphine than water in a two-bottle preference test. The cause of this shift in preference was examined with the taste reactivity test which involves the analysis of fixed action patterns elicited by taste solutions infused into rats' mouths. Three morphine concentrations and two levels of motivation were studied. A greater percentage of ingestive taste reactivity responses occurred to the oral morphine infusion in morphine-raised rats than in water-raised rats. These data argue against the idea that enhanced morphine ingestion is caused by anticipation of positive consequences. Instead, they support the idea that rats come to 'like' the flavor of the morphine solution; in other words, the palatability evaluation of the morphine changes, possibly through an association between the flavor and the hedonically positive effects of the morphine.

AB - When rats are forced to drink a morphine solution as their only source of fluid, they eventually reverse their initial preference and drink more morphine than water in a two-bottle preference test. The cause of this shift in preference was examined with the taste reactivity test which involves the analysis of fixed action patterns elicited by taste solutions infused into rats' mouths. Three morphine concentrations and two levels of motivation were studied. A greater percentage of ingestive taste reactivity responses occurred to the oral morphine infusion in morphine-raised rats than in water-raised rats. These data argue against the idea that enhanced morphine ingestion is caused by anticipation of positive consequences. Instead, they support the idea that rats come to 'like' the flavor of the morphine solution; in other words, the palatability evaluation of the morphine changes, possibly through an association between the flavor and the hedonically positive effects of the morphine.

UR - http://www.scopus.com/inward/record.url?scp=0021923011&partnerID=8YFLogxK

U2 - 10.1037/0735-7044.99.2.290

DO - 10.1037/0735-7044.99.2.290

M3 - Article

C2 - 3843713

AN - SCOPUS:0021923011

VL - 99

SP - 290

EP - 300

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

IS - 2

ER -

Zellner D, Berridge KC, Grill HJ, Ternes JW. Rats learn to like the taste of morphine. Behavioral Neuroscience. 1985 Jan 1;99(2):290-300. https://doi.org/10.1037/0735-7044.99.2.290