TY - JOUR
T1 - Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling
AU - Yermolaieva, Olena
AU - Brot, Nathan
AU - Weissbach, Herbert
AU - Heinemann, Stefan H.
AU - Hoshi, Toshinori
PY - 2000/1/4
Y1 - 2000/1/4
N2 - Reactive oxygen species (ROS) and nitric oxide (NO) are important participants in signal transduction that could provide the cellular basis for activity-dependent regulation of neuronal excitability. In young rat cortical brain slices and undifferentiated PC12 cells, paired application of depolarization/agonist stimulation and oxidation induces long-lasting potentiation of subsequent Ca2+ signaling that is reversed by hypoxia. This potentiation critically depends on NO production and involves cellular ROS utilization. The ability to develop the Ca2+ signal potentiation is regulated by the developmental stage of nerve tissue, decreasing markedly in adult rat cortical neurons and differentiated PC12 cells.
AB - Reactive oxygen species (ROS) and nitric oxide (NO) are important participants in signal transduction that could provide the cellular basis for activity-dependent regulation of neuronal excitability. In young rat cortical brain slices and undifferentiated PC12 cells, paired application of depolarization/agonist stimulation and oxidation induces long-lasting potentiation of subsequent Ca2+ signaling that is reversed by hypoxia. This potentiation critically depends on NO production and involves cellular ROS utilization. The ability to develop the Ca2+ signal potentiation is regulated by the developmental stage of nerve tissue, decreasing markedly in adult rat cortical neurons and differentiated PC12 cells.
UR - http://www.scopus.com/inward/record.url?scp=0034602649&partnerID=8YFLogxK
U2 - 10.1073/pnas.97.1.448
DO - 10.1073/pnas.97.1.448
M3 - Article
C2 - 10618438
AN - SCOPUS:0034602649
SN - 0027-8424
VL - 97
SP - 448
EP - 453
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 1
ER -