Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling

Olena Yermolaieva, Nathan Brot, Herbert Weissbach, Stefan H. Heinemann, Toshinori Hoshi

Research output: Contribution to journalArticle

82 Scopus citations


Reactive oxygen species (ROS) and nitric oxide (NO) are important participants in signal transduction that could provide the cellular basis for activity-dependent regulation of neuronal excitability. In young rat cortical brain slices and undifferentiated PC12 cells, paired application of depolarization/agonist stimulation and oxidation induces long-lasting potentiation of subsequent Ca2+ signaling that is reversed by hypoxia. This potentiation critically depends on NO production and involves cellular ROS utilization. The ability to develop the Ca2+ signal potentiation is regulated by the developmental stage of nerve tissue, decreasing markedly in adult rat cortical neurons and differentiated PC12 cells.

Original languageEnglish
Pages (from-to)448-453
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number1
Publication statusPublished - 4 Jan 2000


Cite this