Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling

Olena Yermolaieva; Nathan Brot; Herbert Weissbach; Stefan H. Heinemann; Toshinori Hoshi

doi:10.1073/pnas.97.1.448

Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling

Olena Yermolaieva
, Nathan Brot
, Herbert Weissbach
, Stefan H. Heinemann
, Toshinori Hoshi

Biology

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Reactive oxygen species (ROS) and nitric oxide (NO) are important participants in signal transduction that could provide the cellular basis for activity-dependent regulation of neuronal excitability. In young rat cortical brain slices and undifferentiated PC12 cells, paired application of depolarization/agonist stimulation and oxidation induces long-lasting potentiation of subsequent Ca²⁺ signaling that is reversed by hypoxia. This potentiation critically depends on NO production and involves cellular ROS utilization. The ability to develop the Ca²⁺ signal potentiation is regulated by the developmental stage of nerve tissue, decreasing markedly in adult rat cortical neurons and differentiated PC12 cells.

Original language	English
Pages (from-to)	448-453
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	97
Issue number	1
DOIs	https://doi.org/10.1073/pnas.97.1.448
State	Published - 4 Jan 2000

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abstract = "Reactive oxygen species (ROS) and nitric oxide (NO) are important participants in signal transduction that could provide the cellular basis for activity-dependent regulation of neuronal excitability. In young rat cortical brain slices and undifferentiated PC12 cells, paired application of depolarization/agonist stimulation and oxidation induces long-lasting potentiation of subsequent Ca2+ signaling that is reversed by hypoxia. This potentiation critically depends on NO production and involves cellular ROS utilization. The ability to develop the Ca2+ signal potentiation is regulated by the developmental stage of nerve tissue, decreasing markedly in adult rat cortical neurons and differentiated PC12 cells.",

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AU - Weissbach, Herbert

AU - Heinemann, Stefan H.

AU - Hoshi, Toshinori

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AB - Reactive oxygen species (ROS) and nitric oxide (NO) are important participants in signal transduction that could provide the cellular basis for activity-dependent regulation of neuronal excitability. In young rat cortical brain slices and undifferentiated PC12 cells, paired application of depolarization/agonist stimulation and oxidation induces long-lasting potentiation of subsequent Ca2+ signaling that is reversed by hypoxia. This potentiation critically depends on NO production and involves cellular ROS utilization. The ability to develop the Ca2+ signal potentiation is regulated by the developmental stage of nerve tissue, decreasing markedly in adult rat cortical neurons and differentiated PC12 cells.

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JF - Proceedings of the National Academy of Sciences of the United States of America

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Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling

Abstract

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