Recent Results In Phosphodiesterase Inhibitor Development and CNS Applications

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Phosphodiesterase inhibitor discovery is an established area of research that continues to develop in concert with biological efforts to identify new potential applications for this target family. Selected phosphodiesterase enzymes are established targets for treatment of erectile dysfunction (PDE5) and for various pulmonary and cardiovascular disorders (PDE3 and PDE4). This chapter details recent advances in the development of new selective and potent PDE inhibitors and discuss future applications of these compounds for the treatment of psychiatric and neurological disorders.

Original languageEnglish
Title of host publicationCyclic-Nucleotide Phosphodiesterases in the Central Nervous System
Subtitle of host publicationFrom Biology to Drug Discovery
PublisherWiley Blackwell
Pages115-144
Number of pages30
ISBN (Electronic)9781118836507
ISBN (Print)9780470566688
DOIs
Publication statusPublished - 28 Apr 2014

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Keywords

  • Assays
  • Chemotypes
  • Drug discovery
  • Medicinal chemistry

Cite this

Rotella, D. (2014). Recent Results In Phosphodiesterase Inhibitor Development and CNS Applications. In Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery (pp. 115-144). Wiley Blackwell. https://doi.org/10.1002/9781118836507.ch05