Phosphodiesterase inhibitor discovery is an established area of research that continues to develop in concert with biological efforts to identify new potential applications for this target family. Selected phosphodiesterase enzymes are established targets for treatment of erectile dysfunction (PDE5) and for various pulmonary and cardiovascular disorders (PDE3 and PDE4). This chapter details recent advances in the development of new selective and potent PDE inhibitors and discuss future applications of these compounds for the treatment of psychiatric and neurological disorders.
|Title of host publication||Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System|
|Subtitle of host publication||From Biology to Drug Discovery|
|Number of pages||30|
|State||Published - 28 Apr 2014|
- Drug discovery
- Medicinal chemistry