Recent results in protein kinase inhibition for tropical diseases

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Protein kinases are becoming widely investigated targets for treatment of protozoal parasitic tropical diseases such as malaria and leishmaniasis. The search for potent, selective inhibitors of these parasitic enzymes has been aided by the extensive variety of structures prepared for human diseases. Genomic approaches to target identification and validation have aided the search. Substantial progress has been made and research is continuing to expand in an effort to find safe, effective drug candidates for these difficult to treat and widespread diseases.

Original languageEnglish
Pages (from-to)6788-6793
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number22
DOIs
StatePublished - 15 Nov 2012

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Protein Kinases
Parasitic Diseases
Leishmaniasis
Enzyme Inhibitors
Malaria
Research
Pharmaceutical Preparations

Keywords

  • Parasitic diseases
  • Protein kinase inhibitors

Cite this

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abstract = "Protein kinases are becoming widely investigated targets for treatment of protozoal parasitic tropical diseases such as malaria and leishmaniasis. The search for potent, selective inhibitors of these parasitic enzymes has been aided by the extensive variety of structures prepared for human diseases. Genomic approaches to target identification and validation have aided the search. Substantial progress has been made and research is continuing to expand in an effort to find safe, effective drug candidates for these difficult to treat and widespread diseases.",
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Recent results in protein kinase inhibition for tropical diseases. / Rotella, David.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 22, 15.11.2012, p. 6788-6793.

Research output: Contribution to journalReview article

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