Role of Asp¹³⁹³ in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein

Keyphrases

• Flavoprotein 100%
• Flavin Reduction 100%
• Neuronal Nitric Oxide Synthase (nNOS) 100%
• Nicotinamide Adenine Dinucleotide Phosphate (NADPH) 100%
• Thermodynamics 100%
• H-binding 100%
• Electron Transfer 40%
• Flavin 40%
• Hydride Transfer 40%
• NADPH Oxidase Activity 40%
• Semiquinone 20%
• Side Chain 20%
• Hydrogen Bonds (H-bonds) 20%
• Heme Reduction 20%
• NO Synthesis 20%
• Cytochrome c Reductase 20%
• Reductase Activity 20%
• Reductase Domain 20%
• Inducible Nitric Oxide Synthase 20%
• NADP+ 20%
• Ferricyanide 20%
• Nicotinamide 20%
• Thermodynamic Destabilization 20%
• Negative Charge 20%
• FAD Domain 20%
• Bonding Properties 20%
• Reductase 20%
• Midpoint Potential 20%

Biochemistry, Genetics and Molecular Biology

• Reductase 100%
• Flavoprotein 100%
• Nicotinamide Adenine Dinucleotide Phosphate 100%
• Wild Type 66%
• Electron Transport 66%
• Oxidoreductase 66%
• NAD(P)H Oxidase 66%
• Enzyme 33%
• Semiquinone 33%
• Cytochrome B5 Reductase 33%
• Cytochrome C 33%
• Nitric Oxide Synthase 33%
• Nicotinamide 33%