Searching for the neural basis of reserve against memory decline: Intellectual enrichment linked to larger hippocampal volume in multiple sclerosis

J. F. Sumowski, M. A. Rocca, V. M. Leavitt, G. Riccitelli, J. Sandry, J. Deluca, G. Comi, M. Filippi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background and purpose: Active engagement in intellectually enriching activities (e.g. reading, hobbies) builds 'reserve' against memory decline in elders and persons with multiple sclerosis (MS), but the neural basis for this protective influence of enrichment is unknown. Herein the neuroanatomical basis of reserve against memory decline in MS patients is investigated. Methods: Relapse-onset MS patients (N = 187) underwent 3.0 T magnetic resonance imaging of the brain to quantify T2 lesion volume (T2LV) and normalized volumes of total brain, total white, total grey (using SIENAX) and thalamus, caudate, putamen, pallidum, amygdala and hippocampus (using FIRST). Patients completed a survey quantifying their engagement in early life intellectual enrichment (i.e. reading, hobbies). Verbal and visuospatial episodic memory was assessed with neuropsychological tasks in a representative subsample (N = 97). Results: Controlling for demographics and T2LV, intellectual enrichment was specifically linked to larger normalized hippocampal volume (rp = 0.213, P = 0.004), with no link to other brain volumes/structures. Moreover, greater intellectual enrichment moderated/attenuated the negative relationship between normalized total brain volume (i.e. overall cerebral atrophy) and normalized hippocampal volume (i.e. hippocampal atrophy; P = 0.001) whereby patients who engaged in more early life intellectual enrichment better maintained hippocampal volume in the face of worse overall cerebral atrophy. Finally, the link between greater intellectual enrichment and better memory was partially mediated through larger hippocampal volume. Conclusions: These findings support larger hippocampal volume as one key component of the neuroanatomical basis of reserve against memory decline in MS. These findings are consistent with previous literature on experience-dependent neuroplasticity within the hippocampus.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalEuropean Journal of Neurology
Volume23
Issue number1
DOIs
StatePublished - 1 Jan 2016

Fingerprint

Multiple Sclerosis
Hobbies
Atrophy
Brain
Reading
Hippocampus
Neuronal Plasticity
Globus Pallidus
Episodic Memory
Putamen
Amygdala
Thalamus
Magnetic Resonance Imaging
Demography
Recurrence

Keywords

  • Cognitive disorders
  • Cognitive reserve
  • Hippocampus
  • Memory
  • Multiple sclerosis

Cite this

Sumowski, J. F. ; Rocca, M. A. ; Leavitt, V. M. ; Riccitelli, G. ; Sandry, J. ; Deluca, J. ; Comi, G. ; Filippi, M. / Searching for the neural basis of reserve against memory decline : Intellectual enrichment linked to larger hippocampal volume in multiple sclerosis. In: European Journal of Neurology. 2016 ; Vol. 23, No. 1. pp. 39-44.
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Searching for the neural basis of reserve against memory decline : Intellectual enrichment linked to larger hippocampal volume in multiple sclerosis. / Sumowski, J. F.; Rocca, M. A.; Leavitt, V. M.; Riccitelli, G.; Sandry, J.; Deluca, J.; Comi, G.; Filippi, M.

In: European Journal of Neurology, Vol. 23, No. 1, 01.01.2016, p. 39-44.

Research output: Contribution to journalArticle

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T2 - Intellectual enrichment linked to larger hippocampal volume in multiple sclerosis

AU - Sumowski, J. F.

AU - Rocca, M. A.

AU - Leavitt, V. M.

AU - Riccitelli, G.

AU - Sandry, J.

AU - Deluca, J.

AU - Comi, G.

AU - Filippi, M.

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AB - Background and purpose: Active engagement in intellectually enriching activities (e.g. reading, hobbies) builds 'reserve' against memory decline in elders and persons with multiple sclerosis (MS), but the neural basis for this protective influence of enrichment is unknown. Herein the neuroanatomical basis of reserve against memory decline in MS patients is investigated. Methods: Relapse-onset MS patients (N = 187) underwent 3.0 T magnetic resonance imaging of the brain to quantify T2 lesion volume (T2LV) and normalized volumes of total brain, total white, total grey (using SIENAX) and thalamus, caudate, putamen, pallidum, amygdala and hippocampus (using FIRST). Patients completed a survey quantifying their engagement in early life intellectual enrichment (i.e. reading, hobbies). Verbal and visuospatial episodic memory was assessed with neuropsychological tasks in a representative subsample (N = 97). Results: Controlling for demographics and T2LV, intellectual enrichment was specifically linked to larger normalized hippocampal volume (rp = 0.213, P = 0.004), with no link to other brain volumes/structures. Moreover, greater intellectual enrichment moderated/attenuated the negative relationship between normalized total brain volume (i.e. overall cerebral atrophy) and normalized hippocampal volume (i.e. hippocampal atrophy; P = 0.001) whereby patients who engaged in more early life intellectual enrichment better maintained hippocampal volume in the face of worse overall cerebral atrophy. Finally, the link between greater intellectual enrichment and better memory was partially mediated through larger hippocampal volume. Conclusions: These findings support larger hippocampal volume as one key component of the neuroanatomical basis of reserve against memory decline in MS. These findings are consistent with previous literature on experience-dependent neuroplasticity within the hippocampus.

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