Serendipitous target-based drug discoveries

János Fischer, David Rotella

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Drug discoveries of the past decades are characterized by an increasing knowledge of molecular biology. In the case of target-based drug discovery, the starting point of the research is a known molecular biological target. There are several therapeutic fields, such as hypertension, obstructive airway diseases, diabetes, and chronic myeloid leukemia whose treatment essentially improved by target-based drug discoveries. A short overview of dapagliflozin, trastuzumab emtansine, sofosbuvir, tofacitinib, and apremilast affords recent examples of target-based drug discoveries. In some special cases, however, the initial drug target only initiates the drug discovery to find a lead molecule; however, the final drug product has a different mechanism of action. Examples of such serendipitous drug discoveries are overviewed by examples of drospirenone, escitalopram, ezetimibe, lamotrigine, and omeprazole.

Original languageEnglish
Title of host publicationSuccessful Drug Discovery
Publisherwiley
Pages3-18
Number of pages16
ISBN (Electronic)9783527336852
ISBN (Print)9783527678433
DOIs
StatePublished - 30 Jan 2015

Fingerprint

Drug Discovery
Citalopram
Omeprazole
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pharmaceutical Preparations
Molecular Biology
Hypertension
Research

Keywords

  • Apremilast
  • Dapagliflozin
  • Drospirenone
  • Escitalopram
  • Ezetimibe
  • Lamotrigine
  • Omeprazole
  • Serendipitous target-based drug discoveries
  • Sofosbuvir
  • Target-based drug discovery
  • Tofacitinib
  • Trastuzumab emtansine

Cite this

Fischer, J., & Rotella, D. (2015). Serendipitous target-based drug discoveries. In Successful Drug Discovery (pp. 3-18). wiley. https://doi.org/10.1002/9783527678433.ch1
Fischer, János ; Rotella, David. / Serendipitous target-based drug discoveries. Successful Drug Discovery. wiley, 2015. pp. 3-18
@inbook{25ce9cd853334e23ad117c8f0a50e6f4,
title = "Serendipitous target-based drug discoveries",
abstract = "Drug discoveries of the past decades are characterized by an increasing knowledge of molecular biology. In the case of target-based drug discovery, the starting point of the research is a known molecular biological target. There are several therapeutic fields, such as hypertension, obstructive airway diseases, diabetes, and chronic myeloid leukemia whose treatment essentially improved by target-based drug discoveries. A short overview of dapagliflozin, trastuzumab emtansine, sofosbuvir, tofacitinib, and apremilast affords recent examples of target-based drug discoveries. In some special cases, however, the initial drug target only initiates the drug discovery to find a lead molecule; however, the final drug product has a different mechanism of action. Examples of such serendipitous drug discoveries are overviewed by examples of drospirenone, escitalopram, ezetimibe, lamotrigine, and omeprazole.",
keywords = "Apremilast, Dapagliflozin, Drospirenone, Escitalopram, Ezetimibe, Lamotrigine, Omeprazole, Serendipitous target-based drug discoveries, Sofosbuvir, Target-based drug discovery, Tofacitinib, Trastuzumab emtansine",
author = "J{\'a}nos Fischer and David Rotella",
year = "2015",
month = "1",
day = "30",
doi = "10.1002/9783527678433.ch1",
language = "English",
isbn = "9783527678433",
pages = "3--18",
booktitle = "Successful Drug Discovery",
publisher = "wiley",

}

Fischer, J & Rotella, D 2015, Serendipitous target-based drug discoveries. in Successful Drug Discovery. wiley, pp. 3-18. https://doi.org/10.1002/9783527678433.ch1

Serendipitous target-based drug discoveries. / Fischer, János; Rotella, David.

Successful Drug Discovery. wiley, 2015. p. 3-18.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Serendipitous target-based drug discoveries

AU - Fischer, János

AU - Rotella, David

PY - 2015/1/30

Y1 - 2015/1/30

N2 - Drug discoveries of the past decades are characterized by an increasing knowledge of molecular biology. In the case of target-based drug discovery, the starting point of the research is a known molecular biological target. There are several therapeutic fields, such as hypertension, obstructive airway diseases, diabetes, and chronic myeloid leukemia whose treatment essentially improved by target-based drug discoveries. A short overview of dapagliflozin, trastuzumab emtansine, sofosbuvir, tofacitinib, and apremilast affords recent examples of target-based drug discoveries. In some special cases, however, the initial drug target only initiates the drug discovery to find a lead molecule; however, the final drug product has a different mechanism of action. Examples of such serendipitous drug discoveries are overviewed by examples of drospirenone, escitalopram, ezetimibe, lamotrigine, and omeprazole.

AB - Drug discoveries of the past decades are characterized by an increasing knowledge of molecular biology. In the case of target-based drug discovery, the starting point of the research is a known molecular biological target. There are several therapeutic fields, such as hypertension, obstructive airway diseases, diabetes, and chronic myeloid leukemia whose treatment essentially improved by target-based drug discoveries. A short overview of dapagliflozin, trastuzumab emtansine, sofosbuvir, tofacitinib, and apremilast affords recent examples of target-based drug discoveries. In some special cases, however, the initial drug target only initiates the drug discovery to find a lead molecule; however, the final drug product has a different mechanism of action. Examples of such serendipitous drug discoveries are overviewed by examples of drospirenone, escitalopram, ezetimibe, lamotrigine, and omeprazole.

KW - Apremilast

KW - Dapagliflozin

KW - Drospirenone

KW - Escitalopram

KW - Ezetimibe

KW - Lamotrigine

KW - Omeprazole

KW - Serendipitous target-based drug discoveries

KW - Sofosbuvir

KW - Target-based drug discovery

KW - Tofacitinib

KW - Trastuzumab emtansine

UR - http://www.scopus.com/inward/record.url?scp=85015505823&partnerID=8YFLogxK

U2 - 10.1002/9783527678433.ch1

DO - 10.1002/9783527678433.ch1

M3 - Chapter

AN - SCOPUS:85015505823

SN - 9783527678433

SP - 3

EP - 18

BT - Successful Drug Discovery

PB - wiley

ER -

Fischer J, Rotella D. Serendipitous target-based drug discoveries. In Successful Drug Discovery. wiley. 2015. p. 3-18 https://doi.org/10.1002/9783527678433.ch1