Stereocontrolled Syntheses for the Six Diastereomeric l,2-Dihydroxy-4,5-diaminocyclohexanes: Pt^IIComplexes and P-388 Antitumor Properties

Keyphrases

• 1,2-Diaminocyclohexane 100%
• Antitumor Properties 100%
• Stereocontrolled Synthesis 100%
• Diamine 100%
• Cyclohexanediol 75%
• Diols 50%
• Amino Group 25%
• Osmylation 25%
• Oxirane 25%
• Acetylation 25%
• Stereochemistry 25%
• Room Temperature 12%
• Single Crystal X-ray Structure 12%
• Hydrogenation 12%
• Trans-11 12%
• Ketones 12%
• Single Product 12%
• Sodium Borohydride Reduction 12%
• Regioselectivity 12%
• Cyclohexene 12%
• Complex Formation 12%
• PDCs 12%
• Monoacetylation 12%
• Cyclohexanediamine 12%
• Diacetate 12%
• Cisplatin 12%
• Leukemia 12%
• Toxic Effects 12%
• Azabicyclo 12%
• Acid Hydrolysis 12%
• Olefin Epoxidation 12%
• Protected Species 12%
• Hydroxyl Function 12%
• Cis-trans Isomerization 12%
• Hydroxyl Group 12%
• Cis-9 12%

Chemistry

• Diastereomer 100%
• Antitumor 100%
• Diol 100%
• formation 75%
• Amino Group 50%
• Oxirane 50%
• Hydroxyl 50%
• Osmylation 50%
• Stereochemistry 50%
• Acetylation 50%
• Single Crystalline Solid 25%
• Ambient Reaction Temperature 25%
• Hydrogenation 25%
• Cisplatin 25%
• Toxic 25%
• Alkene 25%
• Cyclohexene 25%
• Ketone 25%
• Sodium Borohydride 25%
• Enzymatic Hydrolysis 25%
• epoxidation 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Leukemia P 388 100%
• Ethylene Oxide 100%
• Alkene 50%
• Cyclohexene Derivative 50%
• Electrolyte Solution 50%
• Acetoacetic Acid 50%
• Cisplatin 50%
• Sodium Borohydride 50%