Studies on a total synthesis of the microbial immunosuppresive agent FR901483

Keyphrases

• Lactams 100%
• Immunosuppressive Agents 100%
• Total Synthesis 100%
• FR901483 100%
• Alcohol 66%
• Natural Products 66%
• Alkylation 66%
• Enolates 66%
• N-Boc 66%
• Chloride 33%
• Ketones 33%
• Azabicyclo 33%
• Hydroxylated 33%
• Cyclization 33%
• Overall Yield 33%
• Tetracyclic 33%
• Silica Gel 33%
• Good Yield 33%
• Stereoselectivity 33%
• Homoallylic Amines 33%
• Simple Steps 33%
• Regioselective Hydroxylation 33%
• Tricycle 33%
• Ring Systems 33%
• Ketal 33%
• N-Acyliminium Ion 33%
• 1,4-Cyclohexanedione 33%
• Iodoacetamide 33%
• Alkoxy 33%
• Annulation 33%
• Davis Chiral Oxaziridine Hydrogenation 33%
• Epimer 33%
• C-ring 33%
• Nonane 33%
• Alcohol Protection 33%
• Keto 33%
• Carbamate 33%

Chemistry

• Lactam 100%
• Enolates 66%
• Natural Product 66%
• Ketone 33%
• Stereoselectivity 33%
• Cyclic Structure 33%
• Nonane 33%
• Ring Formation 33%
• Oxaziridine 33%
• Epimer 33%
• Cyclohexanedione 33%
• Ketal 33%
• Immunosuppressive Agent 33%
• Alkylation 33%
• hydroxylation 33%
• Carbamate 33%