Abstract
Transcranial magnetic stimulation (TMS) can be applied in different paradigms to obtain a measure of various aspects of cortical excitability. These different TMS paradigms provide information about different neurotransmitter systems, enhance our understanding about the pathophysiology of neuropsychiatric conditions, and in the future may be helpful as a guide for pharmacological interventions. In addition, repetitive TMS (rTMS) modulates cortical excitability beyond the duration of the rTMS trains themselves. Depending on rTMS parameters, a lasting inhibition or facilitation of cortical excitability can be induced. These effects can be demonstrated neurophysiologically or by combining rTMS with neuroimaging techniques. The effects do not remain limited to the cortical area directly targeted by rTMS, but affect a wider neural network transynaptically. Modulation of cortical excitability by rTMS may in the future be useful not only as a research tool but also as a therapeutic intervention in neurology, psychiatry, and neurorehabilitation.
| Original language | English |
|---|---|
| Pages (from-to) | 333-343 |
| Number of pages | 11 |
| Journal | Journal of Clinical Neurophysiology |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1 Jan 1998 |
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Keywords
- Cortical excitability
- Neuroimaging
- Repetitive transcranial magnetic stimulation
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Study and modulation of human cortical excitability with transcranial magnetic stimulation. / Pascual-Leone, Alvaro; Tormos, Jose M.; Keenan, Julian; Tarazona, Francisco; Cañete, Carlos; Catalá, Maria D.
In: Journal of Clinical Neurophysiology, Vol. 15, No. 4, 01.01.1998, p. 333-343.Research output: Contribution to journal › Review article › Research › peer-review
TY - JOUR
T1 - Study and modulation of human cortical excitability with transcranial magnetic stimulation
AU - Pascual-Leone, Alvaro
AU - Tormos, Jose M.
AU - Keenan, Julian
AU - Tarazona, Francisco
AU - Cañete, Carlos
AU - Catalá, Maria D.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Transcranial magnetic stimulation (TMS) can be applied in different paradigms to obtain a measure of various aspects of cortical excitability. These different TMS paradigms provide information about different neurotransmitter systems, enhance our understanding about the pathophysiology of neuropsychiatric conditions, and in the future may be helpful as a guide for pharmacological interventions. In addition, repetitive TMS (rTMS) modulates cortical excitability beyond the duration of the rTMS trains themselves. Depending on rTMS parameters, a lasting inhibition or facilitation of cortical excitability can be induced. These effects can be demonstrated neurophysiologically or by combining rTMS with neuroimaging techniques. The effects do not remain limited to the cortical area directly targeted by rTMS, but affect a wider neural network transynaptically. Modulation of cortical excitability by rTMS may in the future be useful not only as a research tool but also as a therapeutic intervention in neurology, psychiatry, and neurorehabilitation.
AB - Transcranial magnetic stimulation (TMS) can be applied in different paradigms to obtain a measure of various aspects of cortical excitability. These different TMS paradigms provide information about different neurotransmitter systems, enhance our understanding about the pathophysiology of neuropsychiatric conditions, and in the future may be helpful as a guide for pharmacological interventions. In addition, repetitive TMS (rTMS) modulates cortical excitability beyond the duration of the rTMS trains themselves. Depending on rTMS parameters, a lasting inhibition or facilitation of cortical excitability can be induced. These effects can be demonstrated neurophysiologically or by combining rTMS with neuroimaging techniques. The effects do not remain limited to the cortical area directly targeted by rTMS, but affect a wider neural network transynaptically. Modulation of cortical excitability by rTMS may in the future be useful not only as a research tool but also as a therapeutic intervention in neurology, psychiatry, and neurorehabilitation.
KW - Cortical excitability
KW - Neuroimaging
KW - Repetitive transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=0031694717&partnerID=8YFLogxK
U2 - 10.1097/00004691-199807000-00005
DO - 10.1097/00004691-199807000-00005
M3 - Review article
VL - 15
SP - 333
EP - 343
JO - Journal of Clinical Neurophysiology
JF - Journal of Clinical Neurophysiology
SN - 0736-0258
IS - 4
ER -