Successes in antiviral drug discovery: a tribute to Nick Meanwell

Research output: Contribution to journalReview articlepeer-review


Drug discovery is a difficult task, and is even more challenging when the target evolves during therapy. Antiviral drug therapy is an excellent example, exemplified by the evolution of therapeutic approaches for treatment of hepatitis C and HIV-1. Nick Meanwell and his colleagues made important contributions leading to molecules for treatment of hepatitis C and HIV-1, each with distinct mechanisms of action. This review summarizes the discovery and impact of these drugs, and will highlight, where applicable, the broader contributions of these discoveries to medicinal chemistry and drug discovery.

Original languageEnglish
Pages (from-to)1239-1248
Number of pages10
JournalMedicinal Chemistry Research
Issue number7
StatePublished - Jul 2023


  • Antiviral drug discovery
  • HIV-1
  • Hepatitis C
  • NS3A protease
  • NS5A
  • NS5B


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