Superior Appetite Hormone Profile after Equivalent Weight Loss by Gastric Bypass Compared to Gastric Banding

Mousumi Bose, Sriram MacHineni, Blanca Oliván, Julio Teixeira, James J. McGinty, Baani Bawa, Ninan Koshy, Antonia Colarusso, Blandine Laferrère

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The goal of this study was to understand the mechanisms of greater weight loss by gastric bypass (GBP) compared to gastric banding (GB) surgery. Obese weight- and age-matched subjects were studied before (T0), after a 12 kg weight loss (T1) by GBP (n = 11) or GB (n = 9), and at 1 year after surgery (T2). peptide YY3-36 (PYY3-36), ghrelin, glucagon-like peptide-1 (GLP-1), leptin, and amylin were measured after an oral glucose challenge. At T1, glucose-stimulated GLP-1 and PYY levels increased significantly after GBP but not GB. Ghrelin levels did not change significantly after either surgery. In spite of equivalent weight loss, leptin and amylin decreased after GBP, but not after GB. At T2, weight loss was greater after GBP than GB (P = 0.003). GLP-1, PYY, and amylin levels did not significantly change from T1 to T2; leptin levels continued to decrease after GBP, but not after GB at T2. Surprisingly, ghrelin area under the curve (AUC) increased 1 year after GBP (P = 0.03). These data show that, at equivalent weight loss, favorable GLP-1 and PYY changes occur after GBP, but not GB, and could explain the difference in weight loss at 1 year. Mechanisms other than weight loss may explain changes of leptin and amylin after GBP.

Original languageEnglish
Pages (from-to)1085-1091
Number of pages7
JournalObesity
Volume18
Issue number6
DOIs
StatePublished - 1 Jan 2010

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Gastric Bypass
Appetite
Weight Loss
Stomach
Hormones
Islet Amyloid Polypeptide
Glucagon-Like Peptide 1
Leptin
Ghrelin
Glucose
Area Under Curve
Weights and Measures

Cite this

Bose, M., MacHineni, S., Oliván, B., Teixeira, J., McGinty, J. J., Bawa, B., ... Laferrère, B. (2010). Superior Appetite Hormone Profile after Equivalent Weight Loss by Gastric Bypass Compared to Gastric Banding. Obesity, 18(6), 1085-1091. https://doi.org/10.1038/oby.2009.473
Bose, Mousumi ; MacHineni, Sriram ; Oliván, Blanca ; Teixeira, Julio ; McGinty, James J. ; Bawa, Baani ; Koshy, Ninan ; Colarusso, Antonia ; Laferrère, Blandine. / Superior Appetite Hormone Profile after Equivalent Weight Loss by Gastric Bypass Compared to Gastric Banding. In: Obesity. 2010 ; Vol. 18, No. 6. pp. 1085-1091.
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Bose, M, MacHineni, S, Oliván, B, Teixeira, J, McGinty, JJ, Bawa, B, Koshy, N, Colarusso, A & Laferrère, B 2010, 'Superior Appetite Hormone Profile after Equivalent Weight Loss by Gastric Bypass Compared to Gastric Banding', Obesity, vol. 18, no. 6, pp. 1085-1091. https://doi.org/10.1038/oby.2009.473

Superior Appetite Hormone Profile after Equivalent Weight Loss by Gastric Bypass Compared to Gastric Banding. / Bose, Mousumi; MacHineni, Sriram; Oliván, Blanca; Teixeira, Julio; McGinty, James J.; Bawa, Baani; Koshy, Ninan; Colarusso, Antonia; Laferrère, Blandine.

In: Obesity, Vol. 18, No. 6, 01.01.2010, p. 1085-1091.

Research output: Contribution to journalArticle

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