TY - JOUR
T1 - Superior Appetite Hormone Profile after Equivalent Weight Loss by Gastric Bypass Compared to Gastric Banding
AU - Bose, Mousumi
AU - MacHineni, Sriram
AU - Oliván, Blanca
AU - Teixeira, Julio
AU - McGinty, James J.
AU - Bawa, Baani
AU - Koshy, Ninan
AU - Colarusso, Antonia
AU - Laferrère, Blandine
N1 - Publisher Copyright:
© 2010 North American Association for the Study of Obesity (NAASO).
PY - 2010
Y1 - 2010
N2 - The goal of this study was to understand the mechanisms of greater weight loss by gastric bypass (GBP) compared to gastric banding (GB) surgery. Obese weight- and age-matched subjects were studied before (T0), after a 12 kg weight loss (T1) by GBP (n = 11) or GB (n = 9), and at 1 year after surgery (T2). peptide YY3-36 (PYY3-36), ghrelin, glucagon-like peptide-1 (GLP-1), leptin, and amylin were measured after an oral glucose challenge. At T1, glucose-stimulated GLP-1 and PYY levels increased significantly after GBP but not GB. Ghrelin levels did not change significantly after either surgery. In spite of equivalent weight loss, leptin and amylin decreased after GBP, but not after GB. At T2, weight loss was greater after GBP than GB (P = 0.003). GLP-1, PYY, and amylin levels did not significantly change from T1 to T2; leptin levels continued to decrease after GBP, but not after GB at T2. Surprisingly, ghrelin area under the curve (AUC) increased 1 year after GBP (P = 0.03). These data show that, at equivalent weight loss, favorable GLP-1 and PYY changes occur after GBP, but not GB, and could explain the difference in weight loss at 1 year. Mechanisms other than weight loss may explain changes of leptin and amylin after GBP.
AB - The goal of this study was to understand the mechanisms of greater weight loss by gastric bypass (GBP) compared to gastric banding (GB) surgery. Obese weight- and age-matched subjects were studied before (T0), after a 12 kg weight loss (T1) by GBP (n = 11) or GB (n = 9), and at 1 year after surgery (T2). peptide YY3-36 (PYY3-36), ghrelin, glucagon-like peptide-1 (GLP-1), leptin, and amylin were measured after an oral glucose challenge. At T1, glucose-stimulated GLP-1 and PYY levels increased significantly after GBP but not GB. Ghrelin levels did not change significantly after either surgery. In spite of equivalent weight loss, leptin and amylin decreased after GBP, but not after GB. At T2, weight loss was greater after GBP than GB (P = 0.003). GLP-1, PYY, and amylin levels did not significantly change from T1 to T2; leptin levels continued to decrease after GBP, but not after GB at T2. Surprisingly, ghrelin area under the curve (AUC) increased 1 year after GBP (P = 0.03). These data show that, at equivalent weight loss, favorable GLP-1 and PYY changes occur after GBP, but not GB, and could explain the difference in weight loss at 1 year. Mechanisms other than weight loss may explain changes of leptin and amylin after GBP.
UR - http://www.scopus.com/inward/record.url?scp=77952954687&partnerID=8YFLogxK
U2 - 10.1038/oby.2009.473
DO - 10.1038/oby.2009.473
M3 - Article
C2 - 20057364
AN - SCOPUS:77952954687
SN - 1930-7381
VL - 18
SP - 1085
EP - 1091
JO - Obesity
JF - Obesity
IS - 6
ER -
