The development of novel and selective p56(lck) tyrosine kinase inhibitors

James L. Bullington, Julie C. Cameron, Janet E. Davis, John H. Dodd, Crafford A. Harris, James R. Henry, J. Lee Pellegrino-Gensey, Kenneth C. Rupert, John Siekierka

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56(lck), is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56(lck).

Original languageEnglish
Pages (from-to)2489-2494
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number18
DOIs
StatePublished - 22 Sep 1998

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Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Protein-Tyrosine Kinases
Signal transduction
T-cells
T-Cell Antigen Receptor
Natural Killer Cells
Signal Transduction
Chemical activation
T-Lymphocytes

Cite this

Bullington, J. L., Cameron, J. C., Davis, J. E., Dodd, J. H., Harris, C. A., Henry, J. R., ... Siekierka, J. (1998). The development of novel and selective p56(lck) tyrosine kinase inhibitors. Bioorganic and Medicinal Chemistry Letters, 8(18), 2489-2494. https://doi.org/10.1016/S0960-894X(98)00445-4
Bullington, James L. ; Cameron, Julie C. ; Davis, Janet E. ; Dodd, John H. ; Harris, Crafford A. ; Henry, James R. ; Pellegrino-Gensey, J. Lee ; Rupert, Kenneth C. ; Siekierka, John. / The development of novel and selective p56(lck) tyrosine kinase inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 1998 ; Vol. 8, No. 18. pp. 2489-2494.
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Bullington, JL, Cameron, JC, Davis, JE, Dodd, JH, Harris, CA, Henry, JR, Pellegrino-Gensey, JL, Rupert, KC & Siekierka, J 1998, 'The development of novel and selective p56(lck) tyrosine kinase inhibitors', Bioorganic and Medicinal Chemistry Letters, vol. 8, no. 18, pp. 2489-2494. https://doi.org/10.1016/S0960-894X(98)00445-4

The development of novel and selective p56(lck) tyrosine kinase inhibitors. / Bullington, James L.; Cameron, Julie C.; Davis, Janet E.; Dodd, John H.; Harris, Crafford A.; Henry, James R.; Pellegrino-Gensey, J. Lee; Rupert, Kenneth C.; Siekierka, John.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 8, No. 18, 22.09.1998, p. 2489-2494.

Research output: Contribution to journalArticle

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