The development of novel and selective p56(lck) tyrosine kinase inhibitors

James L. Bullington; Julie C. Cameron; Janet E. Davis; John H. Dodd; Crafford A. Harris; James R. Henry; J. Lee Pellegrino-Gensey; Kenneth C. Rupert; John J. Siekierka

doi:10.1016/S0960-894X(98)00445-4

The development of novel and selective p56(lck) tyrosine kinase inhibitors

James L. Bullington
, Julie C. Cameron
, Janet E. Davis
, John H. Dodd
, Crafford A. Harris
, James R. Henry
, J. Lee Pellegrino-Gensey
, Kenneth C. Rupert
, John J. Siekierka

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56(lck), is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56(lck).

Original language	English
Pages (from-to)	2489-2494
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	18
DOIs	https://doi.org/10.1016/S0960-894X(98)00445-4
State	Published - 22 Sep 1998

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title = "The development of novel and selective p56(lck) tyrosine kinase inhibitors",

abstract = "Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56(lck), is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56(lck).",

author = "Bullington, \{James L.\} and Cameron, \{Julie C.\} and Davis, \{Janet E.\} and Dodd, \{John H.\} and Harris, \{Crafford A.\} and Henry, \{James R.\} and Pellegrino-Gensey, \{J. Lee\} and Rupert, \{Kenneth C.\} and Siekierka, \{John J.\}",

year = "1998",

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T1 - The development of novel and selective p56(lck) tyrosine kinase inhibitors

AU - Bullington, James L.

AU - Cameron, Julie C.

AU - Davis, Janet E.

AU - Dodd, John H.

AU - Harris, Crafford A.

AU - Henry, James R.

AU - Pellegrino-Gensey, J. Lee

AU - Rupert, Kenneth C.

AU - Siekierka, John J.

PY - 1998/9/22

Y1 - 1998/9/22

N2 - Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56(lck), is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56(lck).

AB - Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56(lck), is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56(lck).

UR - https://www.scopus.com/pages/publications/0032558527

U2 - 10.1016/S0960-894X(98)00445-4

DO - 10.1016/S0960-894X(98)00445-4

M3 - Article

C2 - 9873567

AN - SCOPUS:0032558527

SN - 0960-894X

VL - 8

SP - 2489

EP - 2494

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 18

ER -

The development of novel and selective p56(lck) tyrosine kinase inhibitors

Abstract

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