The development of novel and selective p56(lck) tyrosine kinase inhibitors

James L. Bullington; Julie C. Cameron; Janet E. Davis; John H. Dodd; Crafford A. Harris; James R. Henry; J. Lee Pellegrino-Gensey; Kenneth C. Rupert; John J. Siekierka

doi:10.1016/S0960-894X(98)00445-4

The development of novel and selective p56(lck) tyrosine kinase inhibitors

James L. Bullington, Julie C. Cameron, Janet E. Davis, John H. Dodd, Crafford A. Harris, James R. Henry, J. Lee Pellegrino-Gensey, Kenneth C. Rupert, John J. Siekierka

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56(lck), is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56(lck).

Original language	English
Pages (from-to)	2489-2494
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	18
DOIs	https://doi.org/10.1016/S0960-894X(98)00445-4
State	Published - 22 Sep 1998

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title = "The development of novel and selective p56(lck) tyrosine kinase inhibitors",

abstract = "Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56(lck), is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56(lck).",

author = "Bullington, \{James L.\} and Cameron, \{Julie C.\} and Davis, \{Janet E.\} and Dodd, \{John H.\} and Harris, \{Crafford A.\} and Henry, \{James R.\} and Pellegrino-Gensey, \{J. Lee\} and Rupert, \{Kenneth C.\} and Siekierka, \{John J.\}",

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AU - Bullington, James L.

AU - Cameron, Julie C.

AU - Davis, Janet E.

AU - Dodd, John H.

AU - Harris, Crafford A.

AU - Henry, James R.

AU - Pellegrino-Gensey, J. Lee

AU - Rupert, Kenneth C.

AU - Siekierka, John J.

PY - 1998/9/22

Y1 - 1998/9/22

N2 - Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56(lck), is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56(lck).

AB - Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56(lck), is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56(lck).

UR - https://www.scopus.com/pages/publications/0032558527

U2 - 10.1016/S0960-894X(98)00445-4

DO - 10.1016/S0960-894X(98)00445-4

M3 - Article

C2 - 9873567

AN - SCOPUS:0032558527

SN - 0960-894X

VL - 8

SP - 2489

EP - 2494

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 18

ER -

The development of novel and selective p56(lck) tyrosine kinase inhibitors

Abstract

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