The Disruptive Effects of Estrogen Removal Before Puberty on Risk for Binge Eating in Female Rats

Kelly L. Klump; Elaine B. Sinclair; Britny A. Hildebrandt; Deborah A. Kashy; Shannon O’Connor; Megan E. Mikhail; Kristen M. Culbert; Alexander Johnson; Cheryl L. Sisk

doi:10.1177/2167702620921343

The Disruptive Effects of Estrogen Removal Before Puberty on Risk for Binge Eating in Female Rats

Kelly L. Klump, Elaine B. Sinclair, Britny A. Hildebrandt, Deborah A. Kashy, Shannon O’Connor, Megan E. Mikhail, Kristen M. Culbert, Alexander Johnson, Cheryl L. Sisk

Psychology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Recent research suggests that estrogen is protective against binge eating in adult females and that pubertal estrogen may be critical for these effects. Nonetheless, to date, no study has examined the role of pubertal estrogen in adult binge-eating phenotypes in females, potentially because of difficulties experimentally manipulating estrogen in humans to examine causal effects. We used a novel animal model to examine whether estrogen removal before puberty (via prepubertal ovariectomy, or P-OVX) increased rates of binge-eating-prone (BEP) phenotypes in adulthood in female rats. Seventy-seven P-OVX rats and 79 intact rats were followed from prepuberty into adulthood and phenotyped for BEP status in adulthood. Results showed significantly increased rates (~2–8 times higher) of adult BEP phenotypes in P-OVX compared with intact rats. Findings confirm that estrogen removal substantially increases later risk for binge eating in females, potentially by disrupting typical adolescent brain development.

Original language	English
Pages (from-to)	839-856
Number of pages	18
Journal	Clinical Psychological Science
Volume	8
Issue number	5
DOIs	https://doi.org/10.1177/2167702620921343
State	Published - 1 Sep 2020

Keywords

animals
binge eating
estrogen
progesterone
puberty

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abstract = "Recent research suggests that estrogen is protective against binge eating in adult females and that pubertal estrogen may be critical for these effects. Nonetheless, to date, no study has examined the role of pubertal estrogen in adult binge-eating phenotypes in females, potentially because of difficulties experimentally manipulating estrogen in humans to examine causal effects. We used a novel animal model to examine whether estrogen removal before puberty (via prepubertal ovariectomy, or P-OVX) increased rates of binge-eating-prone (BEP) phenotypes in adulthood in female rats. Seventy-seven P-OVX rats and 79 intact rats were followed from prepuberty into adulthood and phenotyped for BEP status in adulthood. Results showed significantly increased rates (~2–8 times higher) of adult BEP phenotypes in P-OVX compared with intact rats. Findings confirm that estrogen removal substantially increases later risk for binge eating in females, potentially by disrupting typical adolescent brain development.",

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AU - Kashy, Deborah A.

AU - O’Connor, Shannon

AU - Mikhail, Megan E.

AU - Culbert, Kristen M.

AU - Johnson, Alexander

AU - Sisk, Cheryl L.

N1 - Publisher Copyright: © The Author(s) 2020.

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N2 - Recent research suggests that estrogen is protective against binge eating in adult females and that pubertal estrogen may be critical for these effects. Nonetheless, to date, no study has examined the role of pubertal estrogen in adult binge-eating phenotypes in females, potentially because of difficulties experimentally manipulating estrogen in humans to examine causal effects. We used a novel animal model to examine whether estrogen removal before puberty (via prepubertal ovariectomy, or P-OVX) increased rates of binge-eating-prone (BEP) phenotypes in adulthood in female rats. Seventy-seven P-OVX rats and 79 intact rats were followed from prepuberty into adulthood and phenotyped for BEP status in adulthood. Results showed significantly increased rates (~2–8 times higher) of adult BEP phenotypes in P-OVX compared with intact rats. Findings confirm that estrogen removal substantially increases later risk for binge eating in females, potentially by disrupting typical adolescent brain development.

AB - Recent research suggests that estrogen is protective against binge eating in adult females and that pubertal estrogen may be critical for these effects. Nonetheless, to date, no study has examined the role of pubertal estrogen in adult binge-eating phenotypes in females, potentially because of difficulties experimentally manipulating estrogen in humans to examine causal effects. We used a novel animal model to examine whether estrogen removal before puberty (via prepubertal ovariectomy, or P-OVX) increased rates of binge-eating-prone (BEP) phenotypes in adulthood in female rats. Seventy-seven P-OVX rats and 79 intact rats were followed from prepuberty into adulthood and phenotyped for BEP status in adulthood. Results showed significantly increased rates (~2–8 times higher) of adult BEP phenotypes in P-OVX compared with intact rats. Findings confirm that estrogen removal substantially increases later risk for binge eating in females, potentially by disrupting typical adolescent brain development.

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The Disruptive Effects of Estrogen Removal Before Puberty on Risk for Binge Eating in Female Rats

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Keywords

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