In this paper, we present a model for multi-strain diseases with antibodydependent enhancement (ADE) with single strain vaccination. The phenomenon of ADE can be described as the increase in the viral growth rate in a secondary infection after recovery from a primary infection of a different disease strain. Using center manifold analysis, a relation between the primary and secondary infection classes is derived on a lower dimensional space. We then examine the effect of single strain vaccination on the dynamics.
|Title of host publication||Frontiers of Applied and Computational Mathematics|
|Subtitle of host publication||New Jersey Institute of Technology, USA, 19 - 21 May 2008|
|Publisher||World Scientific Publishing Co.|
|Number of pages||8|
|State||Published - 1 Jan 2008|
- Antibody dependent enhancement
- Center manifold