The effect of post-conditioning exposure to morphine on the retention of a morphine-induced conditioned taste aversion

W. J. Jacobs, D. A. Zellner, V. M. LoLordo, A. L. Riley

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

In the following experiment, multiple injections of morphine sulfate following the acquisition of a morphine-induced taste aversion had no effect on the retention of the previously acquired aversion. Post-conditioning injections of morphine resulted in the development of physical dependence to morphine and led to a decrement in the ability of morphine to induce a subsequent aversion to a second novel taste. This failure of post-conditioning exposures to morphine to affect a previously acquired morphine-induced taste aversion even though tolerance to morphine had occured was discussed in the context of Rescorla's event-memory model of conditioning.

Original languageEnglish
Pages (from-to)779-785
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Volume14
Issue number6
DOIs
StatePublished - Jun 1981

Keywords

  • Blocking
  • Conditioned taste aversion
  • Dependence
  • Morphine
  • Naloxone
  • Tolerance
  • UCS habituation
  • UCS pre-exposure

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