The effect of Pyrrolo[3,4-c]carbazole derivatives on spinal cord ChAT activity

David P. Rotella, Marcie A. Glicksman, J. Eric Prantner, Nicola T. Neff, Robert L. Hudkins

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Pyrrolo[3,4-c]carbazole derivatives were prepared as potential neurotrophic agents. The compounds were assayed for their ability to stimulate choline acetyltransferase (ChAT) activity in embryonic rat spinal cord cultures. These simplified K252a derivatives, although less potent and efficacious, have led to the identification of minimal structural requirements for K252a neurotrophic activity.

Original languageEnglish
Pages (from-to)1167-1170
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number11
DOIs
StatePublished - 8 Jun 1995

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