The effect of Pyrrolo[3,4-c]carbazole derivatives on spinal cord ChAT activity

David P. Rotella; Marcie A. Glicksman; J. Eric Prantner; Nicola T. Neff; Robert L. Hudkins

doi:10.1016/0960-894X(95)00188-Y

The effect of Pyrrolo[3,4-c]carbazole derivatives on spinal cord ChAT activity

David P. Rotella
, Marcie A. Glicksman
, J. Eric Prantner
, Nicola T. Neff
, Robert L. Hudkins

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Pyrrolo[3,4-c]carbazole derivatives were prepared as potential neurotrophic agents. The compounds were assayed for their ability to stimulate choline acetyltransferase (ChAT) activity in embryonic rat spinal cord cultures. These simplified K252a derivatives, although less potent and efficacious, have led to the identification of minimal structural requirements for K252a neurotrophic activity.

Original language	English
Pages (from-to)	1167-1170
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	11
DOIs	https://doi.org/10.1016/0960-894X(95)00188-Y
State	Published - 8 Jun 1995

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10.1016/0960-894X(95)00188-Y

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title = "The effect of Pyrrolo[3,4-c]carbazole derivatives on spinal cord ChAT activity",

abstract = "Pyrrolo[3,4-c]carbazole derivatives were prepared as potential neurotrophic agents. The compounds were assayed for their ability to stimulate choline acetyltransferase (ChAT) activity in embryonic rat spinal cord cultures. These simplified K252a derivatives, although less potent and efficacious, have led to the identification of minimal structural requirements for K252a neurotrophic activity.",

author = "Rotella, \{David P.\} and Glicksman, \{Marcie A.\} and Prantner, \{J. Eric\} and Neff, \{Nicola T.\} and Hudkins, \{Robert L.\}",

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T1 - The effect of Pyrrolo[3,4-c]carbazole derivatives on spinal cord ChAT activity

AU - Rotella, David P.

AU - Glicksman, Marcie A.

AU - Prantner, J. Eric

AU - Neff, Nicola T.

AU - Hudkins, Robert L.

PY - 1995/6/8

Y1 - 1995/6/8

N2 - Pyrrolo[3,4-c]carbazole derivatives were prepared as potential neurotrophic agents. The compounds were assayed for their ability to stimulate choline acetyltransferase (ChAT) activity in embryonic rat spinal cord cultures. These simplified K252a derivatives, although less potent and efficacious, have led to the identification of minimal structural requirements for K252a neurotrophic activity.

AB - Pyrrolo[3,4-c]carbazole derivatives were prepared as potential neurotrophic agents. The compounds were assayed for their ability to stimulate choline acetyltransferase (ChAT) activity in embryonic rat spinal cord cultures. These simplified K252a derivatives, although less potent and efficacious, have led to the identification of minimal structural requirements for K252a neurotrophic activity.

UR - https://www.scopus.com/pages/publications/0029065841

U2 - 10.1016/0960-894X(95)00188-Y

DO - 10.1016/0960-894X(95)00188-Y

M3 - Article

AN - SCOPUS:0029065841

SN - 0960-894X

VL - 5

SP - 1167

EP - 1170

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 11

ER -

The effect of Pyrrolo[3,4-c]carbazole derivatives on spinal cord ChAT activity

Abstract

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