The high-resolution NMR structure of the R21A Spc-SH3:P41 complex: Understanding the determinants of binding affinity by comparison with Abl-SH3

Keyphrases

• Binding Affinity 100%
• NMR Structure 100%
• Spectrin 100%
• High-resolution NMR 100%
• SH3 Domain 100%
• Low Affinity 25%
• Arginine 16%
• High Affinity 16%
• Binding Energetics 16%
• Water Molecule 16%
• Amino Acids 8%
• Complex Structure 8%
• Binding Site 8%
• Thermodynamic Analysis 8%
• Rational Design 8%
• Side Chain 8%
• Effective Strategies 8%
• Thermodynamic Parameters 8%
• Cellular Processes 8%
• Amides 8%
• Strong Reduction 8%
• Thermodynamics 8%
• Structural Difference 8%
• Small Protein 8%
• Drug Design 8%
• Differential Scanning Calorimetry 8%
• 4-fold 8%
• Protein-ligand 8%
• Area Calculation 8%
• Binding Enthalpy 8%
• Decapeptide 8%
• Deuterium Experiment 8%
• Isothermal Titration 8%
• Proline-rich Sequences 8%
• Specificity Pocket 8%
• Abl Tyrosine Kinase 8%
• Steric Clash 8%
• Conformational Effect 8%
• Protein-ligand Interaction 8%
• Protein Module 8%
• Binding Entropy 8%
• Buried Water 8%
• Conformational Flexibility 8%
• NMR Data 8%
• Solvent Accessible Surface Area 8%
• High-resolution Structures 8%

Biochemistry, Genetics and Molecular Biology

• Binding Affinity 100%
• Spectrin 100%
• SH3 Domain 100%
• Energy Transfer 25%
• Arginine 16%
• Amino Acids 8%
• Binding Site 8%
• Receptor Tyrosine Kinase 8%
• Tyrosine Kinase 8%
• Differential Scanning Calorimetry 8%
• Protein Ligand 8%
• Accessible Surface Area 8%
• Enthalpy 8%
• Alanine 8%
• Proline 8%
• Protein-Ligand Interaction 8%