The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation

Yongjun Lu, Xiuying Ma, Rasna Sabharwal, Vladislav Snitsarev, Donald Morgan, Kamal Rahmouni, Heather A. Drummond, Carol A. Whiteis, Vivian Costa, Margaret Price, Christopher Benson, Michael J. Welsh, Mark W. Chapleau, François M. Abboud

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109 Citations (Scopus)

Abstract

Arterial baroreceptors provide a neural sensory input that reflexly regulates the autonomic drive of circulation. Our goal was to test the hypothesis that a member of the acid-sensing ion channel (ASIC) subfamily of the DEG/ENaC superfamily is an important determinant of the arterial baroreceptor reflex. We found that aortic baroreceptor neurons in the nodose ganglia and their terminals express ASIC2. Conscious ASIC2 null mice developed hypertension, had exaggerated sympathetic and depressed parasympathetic control of the circulation, and a decreased gain of the baroreflex, all indicative of an impaired baroreceptor reflex. Multiple measures of baroreceptor activity each suggest that mechanosensitivity is diminished in ASIC2 null mice. The results define ASIC2 as an important determinant of autonomic circulatory control and of baroreceptor sensitivity. The genetic disruption of ASIC2 recapitulates the pathological dysautonomia seen in heart failure and hypertension and defines a molecular defect that may be relevant to its development.

Original languageEnglish
Pages (from-to)885-897
Number of pages13
JournalNeuron
Volume64
Issue number6
DOIs
StatePublished - 24 Dec 2009

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Pressoreceptors
Ion Channels
Baroreflex
Acid Sensing Ion Channels
Primary Dysautonomias
Nodose Ganglion
Hypertension
Heart Failure
Neurons

Keywords

  • MOLNEURO
  • SIGNALING

Cite this

Lu, Yongjun ; Ma, Xiuying ; Sabharwal, Rasna ; Snitsarev, Vladislav ; Morgan, Donald ; Rahmouni, Kamal ; Drummond, Heather A. ; Whiteis, Carol A. ; Costa, Vivian ; Price, Margaret ; Benson, Christopher ; Welsh, Michael J. ; Chapleau, Mark W. ; Abboud, François M. / The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation. In: Neuron. 2009 ; Vol. 64, No. 6. pp. 885-897.
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abstract = "Arterial baroreceptors provide a neural sensory input that reflexly regulates the autonomic drive of circulation. Our goal was to test the hypothesis that a member of the acid-sensing ion channel (ASIC) subfamily of the DEG/ENaC superfamily is an important determinant of the arterial baroreceptor reflex. We found that aortic baroreceptor neurons in the nodose ganglia and their terminals express ASIC2. Conscious ASIC2 null mice developed hypertension, had exaggerated sympathetic and depressed parasympathetic control of the circulation, and a decreased gain of the baroreflex, all indicative of an impaired baroreceptor reflex. Multiple measures of baroreceptor activity each suggest that mechanosensitivity is diminished in ASIC2 null mice. The results define ASIC2 as an important determinant of autonomic circulatory control and of baroreceptor sensitivity. The genetic disruption of ASIC2 recapitulates the pathological dysautonomia seen in heart failure and hypertension and defines a molecular defect that may be relevant to its development.",
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Lu, Y, Ma, X, Sabharwal, R, Snitsarev, V, Morgan, D, Rahmouni, K, Drummond, HA, Whiteis, CA, Costa, V, Price, M, Benson, C, Welsh, MJ, Chapleau, MW & Abboud, FM 2009, 'The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation', Neuron, vol. 64, no. 6, pp. 885-897. https://doi.org/10.1016/j.neuron.2009.11.007

The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation. / Lu, Yongjun; Ma, Xiuying; Sabharwal, Rasna; Snitsarev, Vladislav; Morgan, Donald; Rahmouni, Kamal; Drummond, Heather A.; Whiteis, Carol A.; Costa, Vivian; Price, Margaret; Benson, Christopher; Welsh, Michael J.; Chapleau, Mark W.; Abboud, François M.

In: Neuron, Vol. 64, No. 6, 24.12.2009, p. 885-897.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation

AU - Lu, Yongjun

AU - Ma, Xiuying

AU - Sabharwal, Rasna

AU - Snitsarev, Vladislav

AU - Morgan, Donald

AU - Rahmouni, Kamal

AU - Drummond, Heather A.

AU - Whiteis, Carol A.

AU - Costa, Vivian

AU - Price, Margaret

AU - Benson, Christopher

AU - Welsh, Michael J.

AU - Chapleau, Mark W.

AU - Abboud, François M.

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