The localizing value of auditory event-related potentials (P300) in patients with medically intractable temporal lobe epilepsy

Abuhuziefa Abubakr, Ilse Wambacq

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

The localizing value of postictal versus interictal event-related potentials (ERPs) was studied in patients with medically intractable TLE admitted for long-term video EEG monitoring. Ten patients with partial seizures and secondary generalization underwent preictal (upon hospital admission), postictal (≤ 6 h after seizure), and interictal (7-48 h after seizure) ERP recordings of an auditory oddball paradigm. Preictal ERPs were compared to postictal and interictal recordings. Intraclass correlations, transformed into z scores, were utilized to analyze amplitude differences between electrodes placed on the hemisphere ipsilateral versus contralateral to the epileptogenic focus. The results showed that in 9 out of 10 patients the ERP amplitude was reduced in postictal compared to preictal recordings for electrodes placed ipsilateral to the epileptogenic focus (P < 0.0001). However, there was no difference in amplitude between ipsilateral and contralateral electrodes in preictal and interictal recordings. These findings suggest that postictal ERPs are of localizing value in patients with TLE while interictal ERPs are not.

Original languageEnglish
Pages (from-to)692-701
Number of pages10
JournalEpilepsy and Behavior
Volume4
Issue number6
DOIs
StatePublished - 1 Jan 2003

Fingerprint

P300 Event-Related Potentials
Temporal Lobe Epilepsy
Evoked Potentials
Electrodes
Seizures
Drug Resistant Epilepsy
Electroencephalography

Keywords

  • EEG
  • Epilepsy
  • ERP
  • Even-related potentials
  • Lateralization
  • Postictal

Cite this

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title = "The localizing value of auditory event-related potentials (P300) in patients with medically intractable temporal lobe epilepsy",
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The localizing value of auditory event-related potentials (P300) in patients with medically intractable temporal lobe epilepsy. / Abubakr, Abuhuziefa; Wambacq, Ilse.

In: Epilepsy and Behavior, Vol. 4, No. 6, 01.01.2003, p. 692-701.

Research output: Contribution to journalArticleResearchpeer-review

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