The numerical design of a parallel plate flow chamber for investigation of endothelial cell response to shear stress

B. J. Chung, A. M. Robertson, D. G. Peters

    Research output: Contribution to journalArticlepeer-review

    44 Scopus citations

    Abstract

    Parallel plate chambers are frequently used to examine the response of biological cells to a constant wall shear stress. However, the stress can vary more than 80% across the chamber due to end effects. Earlier estimates of the magnitude of this inhomogeneity used boundary layer theory and experiments. Here, the full equations for steady, three-dimensional flow in a novel parallel plate device were solved numerically and used to identify an active test region where the shear stress is within 5% of a constant value. Endothelial cells can be confined to this region to assure a nearly uniform shear stress exposure.

    Original languageEnglish
    Pages (from-to)535-546
    Number of pages12
    JournalComputers and Structures
    Volume81
    Issue number8-11
    DOIs
    StatePublished - May 2003

    Keywords

    • Active test region
    • Endothelial cells
    • Mechanotransduction
    • Parallel plate device
    • Shear stress

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