The numerical design of a parallel plate flow chamber for investigation of endothelial cell response to shear stress

Bong Jae Chung, A. M. Robertson, D. G. Peters

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Parallel plate chambers are frequently used to examine the response of biological cells to a constant wall shear stress. However, the stress can vary more than 80% across the chamber due to end effects. Earlier estimates of the magnitude of this inhomogeneity used boundary layer theory and experiments. Here, the full equations for steady, three-dimensional flow in a novel parallel plate device were solved numerically and used to identify an active test region where the shear stress is within 5% of a constant value. Endothelial cells can be confined to this region to assure a nearly uniform shear stress exposure.

Original languageEnglish
Pages (from-to)535-546
Number of pages12
JournalComputers and Structures
Volume81
Issue number8-11
DOIs
StatePublished - 1 May 2003

Fingerprint

Endothelial Cells
Endothelial cells
Shear Stress
Shear stress
End Effect
Wall Shear Stress
Three-dimensional Flow
Inhomogeneity
Boundary Layer
Vary
Cell
Boundary layers
Estimate
Experiment
Design
Experiments

Keywords

  • Active test region
  • Endothelial cells
  • Mechanotransduction
  • Parallel plate device
  • Shear stress

Cite this

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The numerical design of a parallel plate flow chamber for investigation of endothelial cell response to shear stress. / Chung, Bong Jae; Robertson, A. M.; Peters, D. G.

In: Computers and Structures, Vol. 81, No. 8-11, 01.05.2003, p. 535-546.

Research output: Contribution to journalArticle

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