The presence of polyglucosan bodies in temporal lobe epilepsy

Its role and significance

Abuhuziefa Abubakr, Ilse Wambacq, John E. Donahue, Rosario Zappulla

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Rationale: Mesial temporal sclerosis (MTS) is an important pathology in temporal lobe epilepsy (TLE) and often associated with good surgical outcome, however prognostic factors for surgical outcome are conflicting. The authors examine seizure outcome after surgery for TLE due to MTS, with focus on the presence of polyglucosan bodies (PGBs), and its relation to the epileptogenic process. Methods: Records of 44 consecutive patients with intractable TLE who underwent anterior temporal lobectomy (ATL) at JFK medical center between 1994-2001 were reviewed. Details of clinical, electrophysiological evaluation, and outcome were collected. All slides were reviewed for the presence of MTS. In twenty-one patients with MTS, detailed histology of surgical specimens was reviewed and relative concentration of PGBs was assessed. The postoperative follow-up duration ranges between 28-74 months. Surgical outcome was evaluated according to Engel's classification. Results: Data of fourteen females (mean age 32.8 years) and 7 males (mean age 34.2) were analyzed. PBGs were identified in 10 patients (8 females and 2 males). All 10 patients had good surgical outcome, with 6 patients (60%) being seizure free (class 1) and 4 patients as class 2. While 11 patients (6 males and 5 females) with absent PGB, 72.8% had good surgical outcome. Of these, 7 (63.8%) had class 1, 1 patient had class 2, and 3 patients had class 3&4. Assessing several risk factors, the only significant difference between the two groups was epilepsy duration, which was significantly longer in patients with PGBs (P = 0.011). Conclusion: The histological presence of PGB is associated with long duration of epilepsy and could be the consequence of epilepsy. Despite prolonged duration of epilepsy, the surgical outcome in PGBs +ve is similar to PGBs -ve patients.

Original languageEnglish
Pages (from-to)911-914
Number of pages4
JournalJournal of Clinical Neuroscience
Volume12
Issue number8
DOIs
StatePublished - 1 Nov 2005

Fingerprint

Temporal Lobe Epilepsy
Sclerosis
Epilepsy
Seizures
polyglucosan
Anterior Temporal Lobectomy
Histology
Pathology

Keywords

  • Epilepsy duration
  • MTS
  • Polyglucosan bodies
  • Surgery outcome
  • Temporal lobe epilepsy

Cite this

Abubakr, Abuhuziefa ; Wambacq, Ilse ; Donahue, John E. ; Zappulla, Rosario. / The presence of polyglucosan bodies in temporal lobe epilepsy : Its role and significance. In: Journal of Clinical Neuroscience. 2005 ; Vol. 12, No. 8. pp. 911-914.
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abstract = "Rationale: Mesial temporal sclerosis (MTS) is an important pathology in temporal lobe epilepsy (TLE) and often associated with good surgical outcome, however prognostic factors for surgical outcome are conflicting. The authors examine seizure outcome after surgery for TLE due to MTS, with focus on the presence of polyglucosan bodies (PGBs), and its relation to the epileptogenic process. Methods: Records of 44 consecutive patients with intractable TLE who underwent anterior temporal lobectomy (ATL) at JFK medical center between 1994-2001 were reviewed. Details of clinical, electrophysiological evaluation, and outcome were collected. All slides were reviewed for the presence of MTS. In twenty-one patients with MTS, detailed histology of surgical specimens was reviewed and relative concentration of PGBs was assessed. The postoperative follow-up duration ranges between 28-74 months. Surgical outcome was evaluated according to Engel's classification. Results: Data of fourteen females (mean age 32.8 years) and 7 males (mean age 34.2) were analyzed. PBGs were identified in 10 patients (8 females and 2 males). All 10 patients had good surgical outcome, with 6 patients (60{\%}) being seizure free (class 1) and 4 patients as class 2. While 11 patients (6 males and 5 females) with absent PGB, 72.8{\%} had good surgical outcome. Of these, 7 (63.8{\%}) had class 1, 1 patient had class 2, and 3 patients had class 3&4. Assessing several risk factors, the only significant difference between the two groups was epilepsy duration, which was significantly longer in patients with PGBs (P = 0.011). Conclusion: The histological presence of PGB is associated with long duration of epilepsy and could be the consequence of epilepsy. Despite prolonged duration of epilepsy, the surgical outcome in PGBs +ve is similar to PGBs -ve patients.",
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The presence of polyglucosan bodies in temporal lobe epilepsy : Its role and significance. / Abubakr, Abuhuziefa; Wambacq, Ilse; Donahue, John E.; Zappulla, Rosario.

In: Journal of Clinical Neuroscience, Vol. 12, No. 8, 01.11.2005, p. 911-914.

Research output: Contribution to journalArticleResearchpeer-review

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