The role of enzyme dynamics and tunnelling in catalysing hydride transfer: Studies of distal mutants of dihydrofolate reductase

Keyphrases

• Methylenetetrahydrofolate Reductase (MTHFR) 100%
• Kinetic Isotope Effect 100%
• Enzyme Dynamics 100%
• Tunneling 100%
• Hydride Transfer 100%
• Temperature Dependence 100%
• Transfer Studies 100%
• Escherichia Coli Dihydrofolate Reductase 66%
• Active Sites 33%
• Reduced Rate 33%
• Distal Residues 33%
• Donor-acceptor Distance 33%
• Activation Parameters 33%
• Temperature Activation 33%
• Intrinsic Kinetics 33%
• Dynamic Networks 33%
• H-transfer 33%
• Dependence Parameter 33%
• Reaction Coordinate 33%
• Catalytic Center 33%
• Whole Protein 33%
• Physical Nature 33%
• Potential Surface 33%
• Hydrogen Tunneling 33%

Chemistry

• Kinetic Isotope Effect 100%
• Dihydrofolates 100%
• Chemistry 33%
• Donor 33%
• Surface Potential 33%
• Hydrogen 33%
• Physical Property 33%