Trace elements and cancer risk

A review of the epidemiologic evidence

Stephanie Silvera, Thomas E. Rohan

Research output: Contribution to journalReview articleResearchpeer-review

193 Citations (Scopus)

Abstract

Worldwide, there are more than 10 million new cancer cases each year, and cancer is the cause of approximately 12% of all deaths. Given this, a large number of epidemiologic studies have been undertaken to identify potential risk factors for cancer, amongst which the association with trace elements has received considerable attention. Trace elements, such as selenium, zinc, arsenic, cadmium, and nickel, are found naturally in the environment, and human exposure derives from a variety of sources, including air, drinking water, and food. Trace elements are of particular interest given that the levels of exposure to them are potentially modifiable. In this review, we focus largely on the association between each of the trace elements noted above and risk of cancers of the lung, breast, colorectum, prostate, urinary bladder, and stomach. Overall, the evidence currently available appears to support an inverse association between selenium exposure and prostate cancer risk, and possibly also a reduction in risk with respect to lung cancer, although additional prospective studies are needed. There is also limited evidence for an inverse association between zinc and breast cancer, and again, prospective studies are needed to confirm this. Most studies have reported no association between selenium and risk of breast, colorectal, and stomach cancer, and between zinc and prostate cancer risk. There is compelling evidence in support of positive associations between arsenic and risk of both lung and bladder cancers, and between cadmium and lung cancer risk.

Original languageEnglish
Pages (from-to)7-27
Number of pages21
JournalCancer Causes and Control
Volume18
Issue number1
DOIs
StatePublished - 1 Feb 2007

Fingerprint

Trace Elements
Lung Neoplasms
Selenium
Zinc
Neoplasms
Arsenic
Breast Neoplasms
Cadmium
Prostatic Neoplasms
Prospective Studies
Risk Reduction Behavior
Nickel
Urinary Bladder Neoplasms
Drinking Water
Stomach Neoplasms
Epidemiologic Studies
Prostate
Colorectal Neoplasms
Stomach
Urinary Bladder

Keywords

  • Arsenic
  • Cadmium
  • Neoplasms
  • Nickel
  • Selenium
  • Trace elements
  • Zinc

Cite this

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title = "Trace elements and cancer risk: A review of the epidemiologic evidence",
abstract = "Worldwide, there are more than 10 million new cancer cases each year, and cancer is the cause of approximately 12{\%} of all deaths. Given this, a large number of epidemiologic studies have been undertaken to identify potential risk factors for cancer, amongst which the association with trace elements has received considerable attention. Trace elements, such as selenium, zinc, arsenic, cadmium, and nickel, are found naturally in the environment, and human exposure derives from a variety of sources, including air, drinking water, and food. Trace elements are of particular interest given that the levels of exposure to them are potentially modifiable. In this review, we focus largely on the association between each of the trace elements noted above and risk of cancers of the lung, breast, colorectum, prostate, urinary bladder, and stomach. Overall, the evidence currently available appears to support an inverse association between selenium exposure and prostate cancer risk, and possibly also a reduction in risk with respect to lung cancer, although additional prospective studies are needed. There is also limited evidence for an inverse association between zinc and breast cancer, and again, prospective studies are needed to confirm this. Most studies have reported no association between selenium and risk of breast, colorectal, and stomach cancer, and between zinc and prostate cancer risk. There is compelling evidence in support of positive associations between arsenic and risk of both lung and bladder cancers, and between cadmium and lung cancer risk.",
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Trace elements and cancer risk : A review of the epidemiologic evidence. / Silvera, Stephanie; Rohan, Thomas E.

In: Cancer Causes and Control, Vol. 18, No. 1, 01.02.2007, p. 7-27.

Research output: Contribution to journalReview articleResearchpeer-review

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