Use of x-ray co-crystal structures and molecular modeling to design potent and selective nonpeptide inhibitors of cathepsin K

D. P. Rotella, D. S. Yamashita, H. J. Oh, I. N. Uzinskas, K. F. Erhard, A. C. Allen, R. C. Haltiwanger, B. Zhao, W. W. Smith, S. S. Abdel-Meguid, K. D. Alessio, C. A. Jansen, M. S. McQueney, T. A. Tomoszek, M. A. Levy, D. F. Veber

Research output: Contribution to journalComment/debate

Original languageEnglish
Pages (from-to)272-275
Number of pages4
JournalChemtracts
Volume12
Issue number4
StatePublished - 1 Apr 1999

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Cathepsin K
Molecular modeling
Crystal structure
X rays

Cite this

Rotella, D. P., Yamashita, D. S., Oh, H. J., Uzinskas, I. N., Erhard, K. F., Allen, A. C., ... Veber, D. F. (1999). Use of x-ray co-crystal structures and molecular modeling to design potent and selective nonpeptide inhibitors of cathepsin K. Chemtracts, 12(4), 272-275.
Rotella, D. P. ; Yamashita, D. S. ; Oh, H. J. ; Uzinskas, I. N. ; Erhard, K. F. ; Allen, A. C. ; Haltiwanger, R. C. ; Zhao, B. ; Smith, W. W. ; Abdel-Meguid, S. S. ; Alessio, K. D. ; Jansen, C. A. ; McQueney, M. S. ; Tomoszek, T. A. ; Levy, M. A. ; Veber, D. F. / Use of x-ray co-crystal structures and molecular modeling to design potent and selective nonpeptide inhibitors of cathepsin K. In: Chemtracts. 1999 ; Vol. 12, No. 4. pp. 272-275.
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title = "Use of x-ray co-crystal structures and molecular modeling to design potent and selective nonpeptide inhibitors of cathepsin K",
author = "Rotella, {D. P.} and Yamashita, {D. S.} and Oh, {H. J.} and Uzinskas, {I. N.} and Erhard, {K. F.} and Allen, {A. C.} and Haltiwanger, {R. C.} and B. Zhao and Smith, {W. W.} and Abdel-Meguid, {S. S.} and Alessio, {K. D.} and Jansen, {C. A.} and McQueney, {M. S.} and Tomoszek, {T. A.} and Levy, {M. A.} and Veber, {D. F.}",
year = "1999",
month = "4",
day = "1",
language = "English",
volume = "12",
pages = "272--275",
journal = "Chemtracts",
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Rotella, DP, Yamashita, DS, Oh, HJ, Uzinskas, IN, Erhard, KF, Allen, AC, Haltiwanger, RC, Zhao, B, Smith, WW, Abdel-Meguid, SS, Alessio, KD, Jansen, CA, McQueney, MS, Tomoszek, TA, Levy, MA & Veber, DF 1999, 'Use of x-ray co-crystal structures and molecular modeling to design potent and selective nonpeptide inhibitors of cathepsin K', Chemtracts, vol. 12, no. 4, pp. 272-275.

Use of x-ray co-crystal structures and molecular modeling to design potent and selective nonpeptide inhibitors of cathepsin K. / Rotella, D. P.; Yamashita, D. S.; Oh, H. J.; Uzinskas, I. N.; Erhard, K. F.; Allen, A. C.; Haltiwanger, R. C.; Zhao, B.; Smith, W. W.; Abdel-Meguid, S. S.; Alessio, K. D.; Jansen, C. A.; McQueney, M. S.; Tomoszek, T. A.; Levy, M. A.; Veber, D. F.

In: Chemtracts, Vol. 12, No. 4, 01.04.1999, p. 272-275.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Use of x-ray co-crystal structures and molecular modeling to design potent and selective nonpeptide inhibitors of cathepsin K

AU - Rotella, D. P.

AU - Yamashita, D. S.

AU - Oh, H. J.

AU - Uzinskas, I. N.

AU - Erhard, K. F.

AU - Allen, A. C.

AU - Haltiwanger, R. C.

AU - Zhao, B.

AU - Smith, W. W.

AU - Abdel-Meguid, S. S.

AU - Alessio, K. D.

AU - Jansen, C. A.

AU - McQueney, M. S.

AU - Tomoszek, T. A.

AU - Levy, M. A.

AU - Veber, D. F.

PY - 1999/4/1

Y1 - 1999/4/1

UR - http://www.scopus.com/inward/record.url?scp=0032827833&partnerID=8YFLogxK

M3 - Comment/debate

AN - SCOPUS:0032827833

VL - 12

SP - 272

EP - 275

JO - Chemtracts

JF - Chemtracts

SN - 1431-9268

IS - 4

ER -