Vaccinations in disease models with antibody-dependent enhancement

Lora Billings, Amy Fiorillo, Ira B. Schwartz

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


This paper examines the effects of single-strain vaccine campaigns on the dynamics of an epidemic multistrain model with antibody-dependent enhancement (ADE). ADE is a disease spreading process causing individuals with their secondary infection to be more infectious than during their first infection by a different strain. We follow the two-strain ADE model described in Cummings et al. [D.A.T. Cummings, Doctoral Thesis, Johns Hopkins University, 2004] and Schwartz et al. [I.B. Schwartz, L.B. Shaw, D.A.T. Cummings, L. Billings, M. McCrary, D. Burke, Chaotic desynchronization of multi-strain diseases, Phys. Rev. E, 72:art. no. 066201, 2005]. After describing the model and its steady state solutions, we modify it to include vaccine campaigns and explore if there exists vaccination rates that can eradicate one or more strains of a virus with ADE.

Original languageEnglish
Pages (from-to)265-281
Number of pages17
JournalMathematical Biosciences
Issue number2
StatePublished - Feb 2008


  • Antibody-dependent enhancement
  • Epidemics
  • Vaccine


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