Vaccinations in disease models with antibody-dependent enhancement

Lora Billings, Amy Fiorillo, Ira B. Schwartz

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

This paper examines the effects of single-strain vaccine campaigns on the dynamics of an epidemic multistrain model with antibody-dependent enhancement (ADE). ADE is a disease spreading process causing individuals with their secondary infection to be more infectious than during their first infection by a different strain. We follow the two-strain ADE model described in Cummings et al. [D.A.T. Cummings, Doctoral Thesis, Johns Hopkins University, 2004] and Schwartz et al. [I.B. Schwartz, L.B. Shaw, D.A.T. Cummings, L. Billings, M. McCrary, D. Burke, Chaotic desynchronization of multi-strain diseases, Phys. Rev. E, 72:art. no. 066201, 2005]. After describing the model and its steady state solutions, we modify it to include vaccine campaigns and explore if there exists vaccination rates that can eradicate one or more strains of a virus with ADE.

Original languageEnglish
Pages (from-to)265-281
Number of pages17
JournalMathematical Biosciences
Volume211
Issue number2
DOIs
StatePublished - 1 Feb 2008

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Antibody-Dependent Enhancement
Vaccination
disease models
Antibody
Antibodies
Enhancement
vaccination
antibodies
Dependent
Vaccines
Vaccine
Infection
vaccines
Art
Desynchronization
Coinfection
Model
Levenberg-Marquardt
Epidemic Model
arts

Keywords

  • Antibody-dependent enhancement
  • Epidemics
  • Vaccine

Cite this

Billings, Lora ; Fiorillo, Amy ; Schwartz, Ira B. / Vaccinations in disease models with antibody-dependent enhancement. In: Mathematical Biosciences. 2008 ; Vol. 211, No. 2. pp. 265-281.
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Vaccinations in disease models with antibody-dependent enhancement. / Billings, Lora; Fiorillo, Amy; Schwartz, Ira B.

In: Mathematical Biosciences, Vol. 211, No. 2, 01.02.2008, p. 265-281.

Research output: Contribution to journalArticleResearchpeer-review

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