Working memory capacity links cognitive reserve with long-term memory in moderate to severe tbi

A translational approach

Joshua Sandry, John Deluca, Nancy Chiaravalloti

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) can have devastating negative consequences on an individuals’ ability to remember information; however, there is variability among memory impairment resulting from TBI. Some individuals exhibit long-term memory (LTM) impairment while others do not. This variability has been explained, at least in part, by the theory of cognitive reserve (CR). The theory suggests that individuals who have spent significant time engaged in intellectually enriching activities (higher CR) are better able to withstand LTM impairment despite neurological injury. The cognitive mechanisms that underlie this relationship are not well-specified. Recent evidence suggests that working memory (WM) capacity may be one mediating variable that can help explain how/ why cognitive reserve (CR) protects against LTM impairment. The present research tested this hypothesis in a sample of fifty moderate to severe TBI patients. Specific neuropsychological tests were administered to estimate CR, LTM and WM. The results were congruent with a recent theoretical model that implicates WM capacity as a mediating variable in the relationship between CR and LTM (Sobel’s Z = 2.62, p = 0.009). These data corroborate recent findings in an alternate neurological population and suggest that WM is an underlying mechanism of CR. Additional research is necessary to establish whether (1) WM is an important individual difference variable to include in memory rehabilitation trials and (2) to determine whether rehabilitation and treatment strategies that specifically target WM may also lead to complimentary improvements on diagnostic tests of delayed LTM in TBI and other memory impaired populations.

Original languageEnglish
Pages (from-to)59-64
Number of pages6
JournalJournal of Neurology
Volume262
Issue number1
DOIs
StatePublished - 1 Jan 2015

Fingerprint

Cognitive Reserve
Long-Term Memory
Short-Term Memory
Rehabilitation
Aptitude
Neuropsychological Tests
Research
Routine Diagnostic Tests
Individuality
Population
Theoretical Models
Traumatic Brain Injury
Wounds and Injuries

Keywords

  • Brain injuries
  • Cognition
  • Cognitive reserve
  • Memory Disorders
  • Rehabilitation
  • Working memory

Cite this

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abstract = "Traumatic brain injury (TBI) can have devastating negative consequences on an individuals’ ability to remember information; however, there is variability among memory impairment resulting from TBI. Some individuals exhibit long-term memory (LTM) impairment while others do not. This variability has been explained, at least in part, by the theory of cognitive reserve (CR). The theory suggests that individuals who have spent significant time engaged in intellectually enriching activities (higher CR) are better able to withstand LTM impairment despite neurological injury. The cognitive mechanisms that underlie this relationship are not well-specified. Recent evidence suggests that working memory (WM) capacity may be one mediating variable that can help explain how/ why cognitive reserve (CR) protects against LTM impairment. The present research tested this hypothesis in a sample of fifty moderate to severe TBI patients. Specific neuropsychological tests were administered to estimate CR, LTM and WM. The results were congruent with a recent theoretical model that implicates WM capacity as a mediating variable in the relationship between CR and LTM (Sobel’s Z = 2.62, p = 0.009). These data corroborate recent findings in an alternate neurological population and suggest that WM is an underlying mechanism of CR. Additional research is necessary to establish whether (1) WM is an important individual difference variable to include in memory rehabilitation trials and (2) to determine whether rehabilitation and treatment strategies that specifically target WM may also lead to complimentary improvements on diagnostic tests of delayed LTM in TBI and other memory impaired populations.",
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Working memory capacity links cognitive reserve with long-term memory in moderate to severe tbi : A translational approach. / Sandry, Joshua; Deluca, John; Chiaravalloti, Nancy.

In: Journal of Neurology, Vol. 262, No. 1, 01.01.2015, p. 59-64.

Research output: Contribution to journalArticleResearchpeer-review

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